2. Gene
  3. MAP7 - microtubule associated protein 7 Gene

MAP7 - microtubule associated protein 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：微管相关蛋白 7

种属: Homo sapiens

同用名: EMAP115; E-MAP-115

基因 ID: 9053 | 基因类型: protein coding

关于 MAP7

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:136,342,734-136,550,422 (from NCBI)

This gene has 9 transcripts (splice variants), 235 orthologues and 3 paralogues. Broad expression in kidney (RPKM 10.5), brain (RPKM 10.5) and 21 other tissues.

功能概要

该基因的产物是一种微管相关蛋白，主要在上皮来源的细胞中表达。微管相关蛋白被认为参与微管动力学，这对细胞极化和分化至关重要。这种蛋白质已被证明能够稳定微管，并可用于调节微管功能。对相关小鼠蛋白的研究也表明在精子发生所需的微管功能中起着重要作用。已为该基因发现编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2010 年 10 月]

The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

MAP7 基因产物(36)

mRNA Protein Name
NM_001198608.3 NP_001185537.1 ensconsin isoform 1
NM_001198609.2 NP_001185538.1 ensconsin isoform 2
NM_001198611.3 NP_001185540.1 ensconsin isoform 4
NM_001198614.2 NP_001185543.1 ensconsin isoform 1
NM_001198615.3 NP_001185544.1 ensconsin isoform 5
NM_001198616.3 NP_001185545.1 ensconsin isoform 6
NM_001198617.3 NP_001185546.1 ensconsin isoform 7
NM_001198618.2 NP_001185547.1 ensconsin isoform 8
NM_001198619.2 NP_001185548.1 ensconsin isoform 8
NM_001388328.1 NP_001375257.1 ensconsin isoform 2
NM_001388329.1 NP_001375258.1 ensconsin isoform 2
NM_001388330.1 NP_001375259.1 ensconsin isoform 2
NM_001388331.1 NP_001375260.1 ensconsin isoform 9
NM_001388332.1 NP_001375261.1 ensconsin isoform 1
NM_001388333.1 NP_001375262.1 ensconsin isoform 1
NM_001388334.1 NP_001375263.1 ensconsin isoform 10
NM_001388335.1 NP_001375264.1 ensconsin isoform 11
NM_001388336.1 NP_001375265.1 ensconsin isoform 12
NM_001388337.1 NP_001375266.1 ensconsin isoform 12
NM_001388338.1 NP_001375267.1 ensconsin isoform 12
NM_001388339.1 NP_001375268.1 ensconsin isoform 13
NM_001388340.1 NP_001375269.1 ensconsin isoform 4
NM_001388341.1 NP_001375270.1 ensconsin isoform 4
NM_001388342.1 NP_001375271.1 ensconsin isoform 14
NM_001388343.1 NP_001375272.1 ensconsin isoform 15
NM_001388344.1 NP_001375273.1 ensconsin isoform 16
NM_001388345.1 NP_001375274.1 ensconsin isoform 17
NM_001388346.1 NP_001375275.1 ensconsin isoform 17
NM_001388347.1 NP_001375276.1 ensconsin isoform 18
NM_001388348.1 NP_001375277.1 ensconsin isoform 8
NM_001388349.1 NP_001375278.1 ensconsin isoform 8
NM_001388350.1 NP_001375279.1 ensconsin isoform 20
NM_001388351.1 NP_001375280.1 ensconsin isoform 20
NM_001388352.1 NP_001375281.1 ensconsin isoform 21
NM_001388353.1 NP_001375282.1 ensconsin isoform 22
NM_003980.6 NP_003971.1 ensconsin isoform 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
27018634 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAP7 蛋白结构

MAP7

MAP7: MAP7 (E-MAP-115) family (456 - 625)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
蛋白主名 其他名称

ensconsin

dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))

MAP7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross MAP7 Q14244 nleB1 Escherichia coli O157:H7 Q8XBX8
Anti Tag CoIP
27018634
Cross MAP7 Q14244 nleB1 Escherichia coli O157:H7 Q8XBX8
CoIP
27018634
Intra MAP7 Q14244 ZNF114 Homo sapiens Q8NC26
Validated Y2H
32296183
Cross MAP7 Q14244 espL2 Escherichia coli O157:H7 A0A0H3JP21
Anti Tag CoIP
27018634
Intra MAP7 Q14244 CLIP4 Homo sapiens Q8N3C7
Validated Y2H
32296183
Intra MAP7 Q14244 CCDC70 Homo sapiens Q6NSX1
Y2H Prey Pooling
32296183
Intra MAP7 Q14244 CCDC70 Homo sapiens Q6NSX1
Validated Y2H
32296183
Intra MAP7 Q14244 CCDC70 Homo sapiens Q6NSX1
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spondylometaphyseal Dysplasia, Kozlowski Type

Spondylometaphyseal Dysplasia Kozlowski Type

Jequier Kozlowski Skeletal Dysplasia

Smd Kozlowski Type

SMDK

Dysmorphism Arthrogryposis Skeletal Maturation Advanced

Jequier-Kozlowski Syndrome

Skeletal Dysplasia Jequier-Kozlowski Type

Smd, Kozlowski Type
Epiphyseal Dysplasia, Multiple, 4

EDM4

Multiple Epiphyseal Dysplasia 4

Multiple Epiphyseal Dysplasia With Clubfoot

Multiple Epiphyseal Dysplasia Type 4

Multiple Epiphyseal Dysplasia, Autosomal Recessive

Multiple Epiphyseal Dysplasia With Bilayered Patellae

Med4

Polyepiphyseal Dysplasia Type 4

Rmed

Autosomal Recessive Multiple Epiphyseal Dysplasia

Multiple Epiphyseal Dysplasia With Bilateral Patellae

Epiphyseal Dysplasia Multiple 4

Multiple Epiphyseal Dysplasia With Double-Layered Patella

Dysplasia, Epiphyseal, Multiple, Type 4
Barrett'S Adenocarcinoma

Barrett Adenocarcinoma

Adenocarcinoma Arising In Barrett'S Mucosa
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08087 MAP7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08088 MAP7D1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08089 MAP7D2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08090 MAP7D3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MAP7 VGNC VGNC:97499
Rattus norvegicus MAP7 RGD RGD:1308866
Bos taurus MAP7 VGNC VGNC:31210
Macaca mulatta MAP7 VGNC VGNC:97788
Canis familiaris MAP7 VGNC VGNC:42987
Mus musculus MAP7 MGD MGI:1328328
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