SLC7A6 - solute carrier family 7 member 6 Gene

中文名称：溶质载体家族 7 成员 6

种属: Homo sapiens

同用名: LAT3; LAT-2; y+LAT-2

基因 ID: 9057 | 基因类型: protein coding

关于 SLC7A6

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,264,526-68,301,819 (from NCBI)

This gene has 17 transcripts (splice variants), 232 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 11.5), lymph node (RPKM 10.0) and 24 other tissues.

功能概要

启用碱性氨基酸跨膜转运蛋白活性。参与碱性氨基酸的跨膜转运和鸟氨酸转运。位于细胞内膜结合的细胞器和质膜中。 [由基因组资源联盟提供，2022 年 4 月]

Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transmembrane transport and ornithine transport. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC7A6 基因产物(2)

mRNA	Protein	Name
NM_001076785.3	NP_001070253.1	Y+L amino acid transporter 2
NM_003983.6	NP_003974.3	Y+L amino acid transporter 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables L-arginine transmembrane transporter activity	IDA IDA: 通过直接分析推断	11311135	GOA
enables L-lysine:L-arginine antiporter activity	IDA IDA: 通过直接分析推断	10903140	GOA
enables arginine binding	IDA IDA: 通过直接分析推断	19562367	GOA
enables basic amino acid transmembrane transporter activity	IMP IMP: 通过突变表型推断	17197568	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in L-arginine transmembrane transport	IDA IDA: 通过直接分析推断	10903140	GOA
involved in L-arginine transmembrane transport	IMP IMP: 通过突变表型推断	31705628	GOA
involved in L-leucine transport	IDA IDA: 通过直接分析推断	16785209	GOA
involved in neutral amino acid transport	IDA IDA: 通过直接分析推断	10903140	GOA
involved in ornithine transport	IMP IMP: 通过突变表型推断	17197568	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC7A6 蛋白结构

AA_permease_2

0
100
200
300
400
515 a.a.

蛋白主名

其他名称

Y+L amino acid transporter 2

amino acid permease

SLC7A6 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SLC7A6	Q92536	DOLK	Homo sapiens	Q9UPQ8	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lysinuric Protein Intolerance

LPI	Dibasic Amino Aciduria Ii
Hyperdibasic Aminoaciduria	Dibasic Aminoaciduria 2
Dibasicamino Aciduria Ii	Congenital Lysinuria
Lpi - Lysinuric Protein Intolerance

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Cystinuria

CSNU	Cystinuria Type B
Cystinuria Type A	Cystinuria, Type I, Formerly
Csnu1, Formerly	Cystinuria, Type Ii, Formerly
Cystinuria, Type Iii, Formerly	Csnu3, Formerly
Cystinuria, Type Non-I, Formerly	Cystinuria-Lysinuria
Cystinuria-Lysinuria Syndrome	Csnu1
Csnu3	Cystinuria 1
Cystinuria Type A/B	Cystinuria Type I
Cystinuria Type Ii	Cystinuria Type Iii
Cystinuria Type Non-I	Cystinuria, Type A/B
Cystinuria Type 1	Cystinuria - Lysinuria
Csnu - [Cystinuria]	Cystine Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13332	SLC7A6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS13333	SLC7A6OS Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SLC7A6	VGNC	VGNC:34931
Canis familiaris	SLC7A6	VGNC	VGNC:46476
Mus musculus	SLC7A6	MGD	MGI:2142598
Rattus norvegicus	SLC7A6	RGD	RGD:1309193
Macaca mulatta	SLC7A6	VGNC	VGNC:104751
Felis catus	SLC7A6	VGNC	VGNC:65427

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC7A6 - solute carrier family 7 member 6 Gene

关于 SLC7A6

功能概要

SLC7A6 基因产物(2)

SLC7A6 蛋白结构

SLC7A6 蛋白互作信息

关联疾病

直系同源

热门区域

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SLC7A6 - solute carrier family 7 member 6 Gene

关于 SLC7A6

功能概要

SLC7A6 基因产物(2)

SLC7A6 蛋白结构

SLC7A6 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z