2. Gene
  3. SLC13A2 - solute carrier family 13 member 2 Gene

SLC13A2 - solute carrier family 13 member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 13 成员 2

种属: Homo sapiens

同用名: NaCT; NADC1; SDCT1; NaDC-1

基因 ID: 9058 | 基因类型: protein coding

关于 SLC13A2

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,473,644-28,497,781 (from NCBI)

This gene has 6 transcripts (splice variants), 254 orthologues and 5 paralogues. Biased expression in duodenum (RPKM 49.7), small intestine (RPKM 41.0) and 4 other tissues.

功能概要

该基因编码的蛋白质是一种钠偶联的柠檬酸盐转运蛋白，受亲环蛋白 b 的伴侣活性调节。编码的蛋白质可能在肾结石的形成中发挥作用。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene is a sodium-coupled citrate transporter that is regulated by the chaperone activity of Cyclophilin B. The encoded protein may play a role in the formation of kidney stones. [provided by RefSeq, Oct 2016]

SLC13A2 基因产物(4)

mRNA Protein Name
NM_001145975.2 NP_001139447.1 solute carrier family 13 member 2 isoform a
NM_001346683.2 NP_001333612.1 solute carrier family 13 member 2 isoform d
NM_001346684.2 NP_001333613.1 solute carrier family 13 member 2 isoform e
NM_003984.4 NP_003975.1 solute carrier family 13 member 2 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha-ketoglutarate transmembrane transporter activity IDA
IDA: 通过直接分析推断
10894787 GOA
enables fumarate transmembrane transporter activity IDA
IDA: 通过直接分析推断
10894787 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sodium:dicarboxylate symporter activity IDA
IDA: 通过直接分析推断
10894787 GOA
enables succinate transmembrane transporter activity IDA
IDA: 通过直接分析推断
10894787 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in alpha-ketoglutarate transport IDA
IDA: 通过直接分析推断
10894787 GOA
involved in cellular response to lithium ion IDA
IDA: 通过直接分析推断
10894787 GOA
involved in fumarate transport IDA
IDA: 通过直接分析推断
10894787 GOA
involved in succinate transmembrane transport IDA
IDA: 通过直接分析推断
10894787 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
27927654 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC13A2 蛋白结构

Na_sulph_symp

Na_sulph_symp: Sodium:sulfate symporter transmembrane region (6 - 565)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 592 a.a.
蛋白主名 其他名称

solute carrier family 13 member 2

Na(+)-coupled citrate transporter

SLC13A2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC13A2 Q13183 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra SLC13A2 Q13183 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra SLC13A2 Q13183 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra SLC13A2 Q13183 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra SLC13A2 Q13183 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra SLC13A2 Q13183 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra SLC13A2 Q13183 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra SLC13A2 Q13183 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephrolithiasis, Uric Acid

Nephrolithiasis, Uric Acid, Susceptibility To

Uric Acid Urolithiasis

Uric Acid Nephrolithiasis

UAN

Acute Urate Nephropathy

Urolithiasis, Uric Acid

Urolithiasis, Uric Acid, Susceptibility To

Uric Acid Renal Calculus
Developmental And Epileptic Encephalopathy 25

Developmental And Epileptic Encephalopathy, 25

Dee25

Developmental And Epileptic Encephalopathy 25, With Amelogenesis Imperfecta

Early Infantile Epileptic Encephalopathy 25

Encephalopathy, Epileptic, Early Infantile, Type 25
Nephrolithiasis

Kidney Stones

Stone - Kidney/Ureter

Kidney Calculi
Hyperoxaluria, Primary, Type Ii

Primary Hyperoxaluria Type 2

D-Glycerate Dehydrogenase Deficiency

Glyoxylate Reductase/Hydroxypyruvate Reductase Deficiency

HP2

Oxalosis Ii

Glyceric Aciduria

L-Glyceric Aciduria

Primary Hyperoxaluria, Type Ii

Oxalosis 2

Hyperoxaluria Primary 2

Hyperoxaluria Primary Type Ii

Ph2

Primary Hyperoxaluria Type Ii
Sialolithiasis

Sialolith

Stone Of Salivary Gland Or Duct

Salivary Gland Calculi

Salivary Gland Stone

Calculus Of Salivary Gland Or Duct

Calculus Of Salivary Gland

Salivary Calculus

Salivary Gland Calculus

Salivary Stone

Salivary Duct Calculi

Sialodocholithiasis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13006 SLC13A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SLC13A2 VGNC VGNC:65197
Rattus norvegicus SLC13A2 RGD RGD:61920
Macaca mulatta SLC13A2 VGNC VGNC:99256
Canis familiaris SLC13A2 VGNC VGNC:46228
Bos taurus SLC13A2 VGNC VGNC:34674
Mus musculus SLC13A2 MGD MGI:1276558
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