2. Gene
  3. SYT7 - synaptotagmin 7 Gene

SYT7 - synaptotagmin 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：突触结合蛋白 7

种属: Homo sapiens

同用名: IPCA7; IPCA-7; SYTVII; PCANAP7; SYT-VII

基因 ID: 9066 | 基因类型: protein coding

关于 SYT7

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,513,714-61,588,387 (from NCBI)

This gene has 10 transcripts (splice variants), 266 orthologues and 31 paralogues. Biased expression in brain (RPKM 15.4), prostate (RPKM 13.8) and 12 other tissues.

功能概要

该基因是突触结合蛋白基因家族的成员，编码的蛋白质与其他家族成员相似，介导突触传递中膜运输的钙依赖性调节。啮齿动物中的一种类似蛋白质介导激素分泌和溶酶体胞吐作用。在人类中，该基因的表达与前列腺癌有关。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 10 月]

This gene is a member of the synaptotagmin gene family and encodes a protein similar to Other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

SYT7 基因产物(7)

mRNA Protein Name
NM_001252065.2 NP_001238994.1 synaptotagmin-7 isoform 1
NM_001300773.2 NP_001287702.1 synaptotagmin-7 isoform 3
NM_001365809.2 NP_001352738.1 synaptotagmin-7 isoform 4
NM_001370210.1 NP_001357139.1 synaptotagmin-7 isoform 5
NM_001370211.1 NP_001357140.1 synaptotagmin-7 isoform 6
NM_001411007.1 NP_001397936.1 synaptotagmin-7 isoform 7
NM_004200.4 NP_004191.2 synaptotagmin-7 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SYT7 蛋白结构

C2

C2: C2 domain (152 - 238)

C2

C2: C2 domain (285 - 370)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
蛋白主名 其他名称

synaptotagmin-7

prostate cancer-associated protein 7

SYT7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SYT7 O43581 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
种属内
SYT7 O43581 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Mucolipidosis
Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder

Infantile Refsum Disease

Infantile Phytanic Acid Storage Disease

PBD1B

Refsum Disease, Infantile

Adrenoleukodystrophy, Autosomal Neonatal

Ird

Mild Pbd-Zsd

Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Pbd-Zsd

Peroxisome Biogenesis Disorder Spectrum

Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Autosomal Neonatal Adrenoleukodystrophy

Refsum Disease Infantile

Peroxisome Biogenesis Disorders

Peroxisome Biogenesis Disorder, Type 1b
Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14119 SYT7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SYT7 VGNC VGNC:65902
Mus musculus SYT7 MGD MGI:1859545
Bos taurus SYT7 VGNC VGNC:56283
Rattus norvegicus SYT7 RGD RGD:62013
Macaca mulatta SYT7 VGNC VGNC:101406
Canis familiaris SYT7 VGNC VGNC:47050
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