2. Gene
  3. PYGO2 - pygopus family PHD finger 2 Gene

PYGO2 - pygopus family PHD finger 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Pygopus 家族 PHD 手指 2

种属: Homo sapiens

同用名: 1190004M21Rik

基因 ID: 90780 | 基因类型: protein coding

关于 PYGO2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,957,026-154,961,782 (from NCBI)

This gene has 3 transcripts (splice variants), 177 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 16.3), ovary (RPKM 15.1) and 25 other tissues.

功能概要

预计将启用多种功能，包括染色质结合活性；组蛋白乙酰转移酶调节活性；和组蛋白结合活性。预测参与肾脏发育和精子细胞核分化。预计在几个过程的上游或内部起作用，包括动物器官发育；染色质结合活性的正调控；组蛋白 H3-K4 甲基化的调控。 β-连环蛋白-TCF 复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including chromatin binding activity; Histone Acetyltransferase regulator activity; and histone binding activity. Predicted to be involved in kidney development and spermatid nucleus differentiation. Predicted to act upstream of or within several processes, including animal organ development; positive regulation of chromatin binding activity; and regulation of histone H3-K4 methylation. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]

PYGO2 基因产物(1)

mRNA Protein Name
NM_138300.4 NP_612157.1 pygopus homolog 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17113272 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of beta-catenin-TCF complex IDA
IDA: 通过直接分析推断
28296634 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PYGO2 蛋白结构

PHD

PHD: PHD-finger (330 - 383)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
蛋白主名 其他名称

pygopus homolog 2

pygopus 2

PYGO2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PYGO2 Q9BRQ0 BCL9 Homo sapiens O00512
TAP
24981860
Intra PYGO2 Q9BRQ0 SORCS3 Homo sapiens Q9UPU3
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Oligospermia
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-157891 JBC117 Inducer / 否
HY-RS11492 PYGO2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PYGO2 VGNC VGNC:33591
Rattus norvegicus PYGO2 RGD RGD:1308535
Felis catus PYGO2 VGNC VGNC:107926
Macaca mulatta PYGO2 VGNC VGNC:76569
Canis familiaris PYGO2 VGNC VGNC:45227
Mus musculus PYGO2 MGD MGI:1916161
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