BCL9 - BCL9 transcription coactivator Gene

中文名称：BCL9 转录辅激活因子

种属: Homo sapiens

同用名: LGS

基因 ID: 607 | 基因类型: protein coding

关于 BCL9

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:147,541,501-147,626,216 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues, 1 paralogue and is associated with 72 phenotypes. Ubiquitous expression in endometrium (RPKM 9.5), ovary (RPKM 8.1) and 25 other tissues.

功能概要

BCL9 与 B 细胞急性淋巴细胞白血病有关。它可能是 1q21 异常的 B 细胞恶性肿瘤的易位靶点。其功能未知。 BCL9 的过度表达可能在 B 细胞恶性肿瘤中具有致病意义。[RefSeq 提供，2008 年 7 月]

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]

BCL9 基因产物(1)

mRNA	Protein	Name
NM_004326.4	NP_004317.2	B-cell CLL/lymphoma 9 protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11955446	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
NOT involved in regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: 通过突变表型推断	19328798	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of beta-catenin-TCF complex	IDA IDA: 通过直接分析推断	28296634	GOA
part of beta-catenin-TCF complex	IPI IPI: 通过物理相互作用推断	11955446	GOA
located in cis-Golgi network	IDA IDA: 通过直接分析推断	23386608	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BCL9 蛋白结构

BCL9

0
300
600
900
1200
1426 a.a.

蛋白主名

其他名称

B-cell CLL/lymphoma 9 protein

B cell CLL/lymphoma 9

BCL9 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	BCL9	O00512	PYGO1	Homo sapiens	Q9Y3Y4	X-Ray Diffraction	18498752
Intra	BCL9	O00512	PYGO1	Homo sapiens	Q9Y3Y4	Pull Down	18498752
Intra	BCL9	O00512	CTNNB1	Homo sapiens	P35222	Pull Down	11955446
Intra	BCL9	O00512	CTNNB1	Homo sapiens	P35222	X-Ray Diffraction	17052462
Intra	BCL9	O00512	PYGO2	Homo sapiens	Q9BRQ0	Anti Tag CoIP	17113272
Intra	BCL9	O00512	PYGO2	Homo sapiens	Q9BRQ0	Anti Tag CoIP	21399610
Cross	BCL9	O00512	pygo	Drosophila melanogaster	Q9V9W8	Y2H	11955446
Cross	BCL9	O00512	arm	Drosophila melanogaster	P18824	Y2H	11955446

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-132300	ZW4864	Inhibitor	97.08%	否
HY-132300A	ZW4864 free base	Inhibitor	99.42%	否
HY-163767	Antitumor agent-171	Inhibitor	/	否
HY-163768	Antitumor agent-172	Inhibitor	/	否
HY-148918	E722-2648	Inhibitor	/	否
HY-161087	β-catenin/BCL9 PPI-IN-1	Inhibitor	/	否
HY-RS01443	BCL9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01444	BCL9L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	BCL9	VGNC	VGNC:70041
Canis familiaris	BCL9	VGNC	VGNC:58090
Rattus norvegicus	BCL9	RGD	RGD:1306934
Bos taurus	BCL9	VGNC	VGNC:58092
Mus musculus	BCL9	MGD	MGI:1924828
Felis catus	BCL9	VGNC	VGNC:60089

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