CCT6A - chaperonin containing TCP1 subunit 6A Gene

中文名称：含伴侣蛋白的 TCP1 亚基 6A

种属: Homo sapiens

同用名: CCT6; Cctz; HTR3; TCPZ; TCP20; MoDP-2; TTCP20; CCT-zeta; CCT-zeta-1; TCP-1-zeta

基因 ID: 908 | 基因类型: protein coding

关于 CCT6A

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:56,051,765-56,063,989 (from NCBI)

This gene has 9 transcripts (splice variants), 122 orthologues and 13 paralogues. Ubiquitous expression in appendix (RPKM 44.1), lymph node (RPKM 38.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种分子伴侣，它是含有伴侣蛋白的 TCP1 复合物 (CCT) 的成员，也称为 TCP1 环状复合物 (TRiC) 。该复合物由两个相同的堆叠环组成，每个环包含八种不同的蛋白质。未折叠的多肽进入复合物的中央空腔，并以依赖 ATP 的方式折叠。该复合物折叠各种蛋白质，包括肌动蛋白和微管蛋白。已经表征了该基因的替代转录剪接变体，编码不同的同种型。此外，已找到该基因的几个假基因。[RefSeq 提供，2010 年 6 月]

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

CCT6A 基因产物(2)

mRNA	Protein	Name
NM_001009186.2	NP_001009186.1	T-complex protein 1 subunit zeta isoform b
NM_001762.4	NP_001753.1	T-complex protein 1 subunit zeta isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables WD40-repeat domain binding	IPI IPI: 通过物理相互作用推断	25467444	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14532270	GOA
enables protein folding chaperone	IDA IDA: 通过直接分析推断	25467444	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in chaperone mediated protein folding independent of cofactor	IMP IMP: 通过突变表型推断	25467444	GOA
involved in chaperone-mediated protein folding	IDA IDA: 通过直接分析推断	22133715	GOA
acts upstream of positive regulation of establishment of protein localization to telomere	IMP IMP: 通过突变表型推断	25467444	GOA
acts upstream of positive regulation of telomere maintenance via telomerase	IMP IMP: 通过突变表型推断	25467444	GOA
involved in protein folding	IDA IDA: 通过直接分析推断	30955883	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	25467444	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of chaperonin-containing T-complex	IDA IDA: 通过直接分析推断	23011926	GOA
part of chaperonin-containing T-complex	IPI IPI: 通过物理相互作用推断	22133715	GOA
located in microtubule	IDA IDA: 通过直接分析推断	21525035	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCT6A 蛋白结构

Cpn60_TCP1

0
100
200
300
400
500
531 a.a.

蛋白主名

其他名称

T-complex protein 1 subunit zeta

T-complex protein 1, zeta subunit

CCT6A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCT6A	P40227	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
种属内	CCT6A	P40227	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
种属内	CCT6A	P40227	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
种属内	CCT6A	P40227	CCT8	Homo sapiens	P50990	Crosslink	30021884
种属内	CCT6A	P40227	CCT8	Homo sapiens	P50990	Anti Tag CoIP	35271311
种属内	CCT6A	P40227	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	CCT6A	P40227	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	CCT6A	P40227	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	CCT6A	P40227	PRKACA	Homo sapiens	P17612	Y2H Array	32814053
种属内	CCT6A	P40227	PRKACA	Homo sapiens	P17612	Validated Y2H	32814053
种属内	CCT6A	P40227	PRKACA	Homo sapiens	P17612	Y2H Pooling	32814053
种属内	CCT6A	P40227	TRIM31	Homo sapiens	Q9BZY9	Validated Y2H	32296183
种属内	CCT6A	P40227	TRIM31	Homo sapiens	Q9BZY9	Y2H Array	32296183
种属内	CCT6A	P40227	TRIM31	Homo sapiens	Q9BZY9	Y2H Prey Pooling	32296183
种属内	CCT6A	P40227	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
种属内	CCT6A	P40227	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
种属内	CCT6A	P40227	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
种属内	CCT6A	P40227	ATXN3	Homo sapiens	P54252	Y2H Array	32814053
种属内	CCT6A	P40227	ATXN3	Homo sapiens	P54252	Validated Y2H	32814053
种属内	CCT6A	P40227	ATXN3	Homo sapiens	P54252	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Morphine Dependence

Axillary Adenitis

Axillary Lymphadenitis

Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 4	SRTD4
Atd4	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 4

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02183	CCT6A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CCT6A	VGNC	VGNC:103797
Bos taurus	CCT6A	VGNC	VGNC:97250
Rattus norvegicus	CCT6A	RGD	RGD:1304763
Felis catus	CCT6A	VGNC	VGNC:80556
Canis familiaris	CCT6A	VGNC	VGNC:38926
Mus musculus	CCT6A	MGD	MGI:107943

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