2. Gene
  3. SLC16A5 - solute carrier family 16 member 5 Gene

SLC16A5 - solute carrier family 16 member 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 16 成员 5

种属: Homo sapiens

同用名: MCT5; MCT6

基因 ID: 9121 | 基因类型: protein coding

关于 SLC16A5

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,087,385-75,110,149 (from NCBI)

This gene has 10 transcripts (splice variants), 269 orthologues and 13 paralogues. Broad expression in lung (RPKM 9.8), duodenum (RPKM 9.3) and 21 other tissues.

功能概要

该基因编码单羧酸转运蛋白家族和主要促进子超家族的成员。编码的蛋白质定位于细胞膜并充当布美他尼的质子连接转运蛋白。编码蛋白的转运受到四种环利尿剂、那格列奈、噻嗪类、丙磺舒和格列本脲的抑制。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 11 月]

This gene encodes a member of the Monocarboxylate Transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

SLC16A5 基因产物(3)

mRNA Protein Name
NM_001271765.2 NP_001258694.1 monocarboxylate transporter 6
NM_001369668.1 NP_001356597.1 monocarboxylate transporter 6
NM_004695.4 NP_004686.1 monocarboxylate transporter 6
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC16A5 蛋白结构

MFS_1

MFS_1: Major Facilitator Superfamily (32 - 297)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

monocarboxylate transporter 6

monocarboxylate transporter 5

SLC16A5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC16A5 O15375 HSPB8 Homo sapiens Q9UJY1
Y2H Prey Pooling
32296183
种属内
SLC16A5 O15375 HSPB8 Homo sapiens Q9UJY1
Validated Y2H
32296183
种属内
SLC16A5 O15375 HSPB8 Homo sapiens Q9UJY1
Y2H Array
32296183
种属内
SLC16A5 O15375 EFEMP2 Homo sapiens O95967
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Allan-Herndon-Dudley Syndrome

AHDS

Allan-Herndon Syndrome

Monocarboxylate Transporter 8 Deficiency

MCT8 DEFICIENCY

Mental Retardation, X-Linked, With Hypotonia

Triiodothyronine Resistance

T3 Resistance

Mental Retardation And Muscular Atrophy

Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency

Intellectual Disability And Muscular Atrophy

Monocarboxylate Transporter-8 Deficiency

T3 Resisitence

Triiodothyronine Resistence

X-Linked Intellectual Disability With Hypotonia

Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency

Monocarboxylate Transporter 8 Deficiency

X-Linked Intellectual Disability-Hypotonia Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13027 SLC16A5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC16A5 MGD MGI:2443515
Macaca mulatta SLC16A5 VGNC VGNC:99257
Rattus norvegicus SLC16A5 RGD RGD:1582896
Bos taurus SLC16A5 VGNC VGNC:34691
Felis catus SLC16A5 VGNC VGNC:65212
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