2. Gene
  3. CCNB2 - cyclin B2 Gene

CCNB2 - cyclin B2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白 B2

种属: Homo sapiens

同用名: HsT17299

基因 ID: 9133 | 基因类型: protein coding

关于 CCNB2

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:59,105,146-59,125,045 (from NCBI)

This gene has 5 transcripts (splice variants), 241 orthologues and 18 paralogues. Biased expression in testis (RPKM 42.1), bone marrow (RPKM 26.8) and 11 other tissues.

功能概要

细胞周期蛋白 B2 是细胞周期蛋白家族的成员，特别是 B 型细胞周期蛋白。 B 型细胞周期蛋白 B1 和 B2 与 p34cdc2 相关，是细胞周期调节机制的重要组成部分。 B1 和 B2 的亚细胞定位不同。细胞周期蛋白 B1 与微管共定位，而细胞周期蛋白 B2 主要与高尔基体区域相关。细胞周期蛋白 B2 也与转化生长因子 β RII 结合，因此细胞周期蛋白 B2/cdc2 可能在转化生长因子 β 介导的细胞周期控制中发挥关键作用。[RefSeq 提供，2008 年 7 月]

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]

CCNB2 基因产物(1)

mRNA Protein Name
NM_004701.4 NP_004692.1 G2/mitotic-specific cyclin-B2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15232106 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCNB2 蛋白结构

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (137 - 261)

Cyclin_C

Cyclin_C: Cyclin, C-terminal domain (264 - 381)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
蛋白主名 其他名称

G2/mitotic-specific cyclin-B2

CCNB2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CCNB2 O95067 FLNA Homo sapiens P21333
Anti Bait CoIP
17408621
种属内
CCNB2 O95067 CDK2 Homo sapiens P24941
GMS
24358021
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Anauxetic Dysplasia 1

Anauxetic Dysplasia

Spondylometaepiphyseal Dysplasia, Menger Type

Spondylometaepiphyseal Dysplasia, Anauxetic Type

Spondyloepimetaphyseal Dysplasia, Anauxetic Type

ANXD1

Anxd

Spondylometaepiphyseal Dysplasia Anauxetic Type

Spondylometaepiphyseal Dysplasia Menger Type

Ad

Spondyloepimetaphyseal Dysplasia, Menger Type

Dysplasia, Anauxetic, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02120 CCNB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CCNB2 VGNC VGNC:60553
Canis familiaris CCNB2 VGNC VGNC:103665
Rattus norvegicus CCNB2 RGD RGD:1308176
Bos taurus CCNB2 VGNC VGNC:26960
Macaca mulatta CCNB2 VGNC VGNC:70721
Mus musculus CCNB2 MGD MGI:88311
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