OSMR - oncostatin M receptor Gene

中文名称：制瘤素 M 受体

种属: Homo sapiens

同用名: OSMRB; PLCA1; IL-31RB; OSMRbeta; IL-31R-beta

基因 ID: 9180 | 基因类型: protein coding

关于 OSMR

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:38,846,012-38,945,579 (from NCBI)

This gene has 5 transcripts (splice variants), 531 orthologues, 23 paralogues and is associated with 2 phenotypes. Ubiquitous expression in gall bladder (RPKM 13.2), placenta (RPKM 11.5) and 24 other tissues.

功能概要

该基因编码 I 型细胞因子受体家族的成员。编码的蛋白质与白介素 6 信号转导异二聚化形成 II 型制瘤素 M 受体，并与白介素 31 受体 A 异二聚化形成白介素 31 受体，从而转导制瘤素 M 和白介素 31 诱导的信号事件。该基因的突变与家族性原发性局部皮肤淀粉样变性有关。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2009 年 12 月]

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

OSMR 基因产物(6)

mRNA	Protein	Name
NM_001168355.3	NP_001161827.1	oncostatin-M-specific receptor subunit beta isoform 2 precursor
NM_001323504.2	NP_001310433.1	oncostatin-M-specific receptor subunit beta isoform 2 precursor
NM_001323505.2	NP_001310434.1	oncostatin-M-specific receptor subunit beta isoform 1 precursor
NM_001323506.2	NP_001310435.1	oncostatin-M-specific receptor subunit beta isoform 3 precursor
NM_001323507.2	NP_001310436.1	oncostatin-M-specific receptor subunit beta isoform 4 precursor
NM_003999.3	NP_003990.1	oncostatin-M-specific receptor subunit beta isoform 1 precursor

OSMR 蛋白结构

fn3

0
200
400
600
800
979 a.a.

蛋白主名

其他名称

oncostatin-M-specific receptor subunit beta

IL-31 receptor subunit beta

OSMR 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	OSMR	Q99650	NDUFS1	Homo sapiens	P28331	Anti Bait CoIP	32807793
种属内	OSMR	Q99650	NDUFS1	Homo sapiens	P28331	PLA	32807793
种属内	OSMR	Q99650	LHX2	Homo sapiens	P50458	Y2H Array	32296183
种属内	OSMR	Q99650	LHX2	Homo sapiens	P50458	Y2H Prey Pooling	32296183
种属内	OSMR	Q99650	NDUFS2	Homo sapiens	O75306	PLA	32807793
种属内	OSMR	Q99650	NDUFS2	Homo sapiens	O75306	Anti Bait CoIP	32807793
种属内	OSMR	Q99650	GPRC5D	Homo sapiens	Q9NZD1	Y2H Array	32296183
种属内	OSMR	Q99650	GPRC5D	Homo sapiens	Q9NZD1	Y2H Prey Pooling	32296183
种属内	OSMR	Q99650	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
种属内	OSMR	Q99650	JAK1	Homo sapiens	P23458	Anti Tag CoIP	33961781
种属内	OSMR	Q99650	JAK1	Homo sapiens	P23458	Anti Tag CoIP	28514442
种属内	OSMR	Q99650	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
种属内	OSMR	Q99650	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
种属内	OSMR	Q99650	HSPA9	Homo sapiens	P38646	Anti Bait CoIP	32807793
种属内	OSMR	Q99650	HSPA9	Homo sapiens	P38646	PLA	32807793
种属内	OSMR	Q99650	ATP5IF1	Homo sapiens	Q9UII2	PLA	32807793
种属内	OSMR	Q99650	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
种属内	OSMR	Q99650	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
种属内	OSMR	Q99650	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
种属内	OSMR	Q99650	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
种属内	OSMR	Q99650	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 OSMR 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72500	OSMR beta Protein, Human (HEK293, His)	Q99650 (E28-S739)	≥95%

关联疾病

疾病名称

别名

Amyloidosis, Primary Localized Cutaneous, 1

PLCA1	Pca
Amyloidosis Ix	Familial Lichen Amyloidosis
Amyloidosis, Primary Cutaneous, 1	Pca1
Lichen Amyloidosis, Familial	Amyloidosis, Familial Cutaneous Lichen
Primary Localized Cutaneous Amyloidosis 1	Familial Primary Localized Cutaneous Amyloidosis-1
Amyloidosis Type 9	Plca
Primary Cutaneous Amyloidosis	Primary Localized Cutaneous Amyloidosis
Amyloidosis, Primary Cutaneous

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Lichen Amyloidosis

Amyloid Lichen	Lichen Amyloidosus
Amyloidosis, Primary Cutaneous

Macular Amyloidosis

Amyloidosis, Macular

Amyloidosis, Primary Localized Cutaneous, 3

Amyloidosis Cutis Dyschromica	PLCA3
Acd	Primary Localized Cutaneous Amyloidosis 3
Amyloidosis Cutis Dyschromia

Allergic Urticaria

Bone Cancer

Malignant Bone Neoplasm	Bone Carcinoma
Bone Neoplasms	Bone Neoplasm
Bone Tumour	Ca - Bone Cancer
Malignant Bone Tumour	Malignant Neoplasm Of Bone
Malignant Osseous Tumor	Neoplasm Of Bone
Osseous Tumor	Osteosarcoma Of Bone
Osteogenic Neoplasm

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09851	OSMR Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	OSMR	VGNC	VGNC:44167
Mus musculus	OSMR	MGD	MGI:1330819
Bos taurus	OSMR	VGNC	VGNC:32475
Felis catus	OSMR	VGNC	VGNC:68659
Rattus norvegicus	OSMR	RGD	RGD:1302983
Macaca mulatta	OSMR	VGNC	VGNC:75721
Macaca fascicularis	OSMR	NCBI	NCBI:102135082
Others	OSMR	NCBI

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