ATP5IF1 - ATP synthase inhibitory factor subunit 1 Gene

中文名称：ATP 合酶抑制因子亚基 1

种属: Homo sapiens

同用名: IP; ATPI; ATPIP; ATPIF1

基因 ID: 93974 | 基因类型: protein coding

关于 ATP5IF1

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,236,124-28,238,100 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 112 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 44.4), colon (RPKM 33.7) and 25 other tissues.

功能概要

该基因编码线粒体 ATP 酶抑制剂。选择性剪接发生在该位点，并且已经鉴定出编码不同亚型的三种转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

ATP5IF1 基因产物(3)

mRNA	Protein	Name
NM_016311.5	NP_057395.1	ATPase inhibitor, mitochondrial isoform 1 precursor
NM_178190.3	NP_835497.1	ATPase inhibitor, mitochondrial isoform 2 precursor
NM_178191.3	NP_835498.1	ATPase inhibitor, mitochondrial isoform 3 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATPase binding	IDA IDA: 通过直接分析推断	15528193	GOA
enables ATPase inhibitor activity	IDA IDA: 通过直接分析推断	12110673	GOA
enables ATPase inhibitor activity	IMP IMP: 通过突变表型推断	24005319	GOA
enables angiostatin binding	IDA IDA: 通过直接分析推断	15528193	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	21106936	GOA
enables mitochondrial proton-transporting ATP synthase complex binding	IDA IDA: 通过直接分析推断	12110673	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mitochondrial depolarization	IMP IMP: 通过突变表型推断	24005319	GOA
involved in negative regulation of ATP-dependent activity	IMP IMP: 通过突变表型推断	24005319	GOA
involved in negative regulation of endothelial cell proliferation	IDA IDA: 通过直接分析推断	15528193	GOA
involved in negative regulation of hydrolase activity	IDA IDA: 通过直接分析推断	15528193	GOA
involved in positive regulation of proteolysis involved in protein catabolic process	IMP IMP: 通过突变表型推断	24005319	GOA
involved in positive regulation of type 2 mitophagy	IMP IMP: 通过突变表型推断	24005319	GOA
involved in regulation of ATP metabolic process	IMP IMP: 通过突变表型推断	24005319	GOA
involved in regulation of protein targeting to mitochondrion	IMP IMP: 通过突变表型推断	24005319	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	15528193	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	12110673	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATP5IF1 蛋白结构

IATP

0
100
106 a.a.

蛋白主名

其他名称

ATPase inhibitor, mitochondrial

ATP synthase F1 subunit epsilon

ATP5IF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ATP5IF1	Q9UII2	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	MECP2	Homo sapiens	P51608	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	GRN	Homo sapiens	P28799-2	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	GRN	Homo sapiens	P28799-2	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	GRN	Homo sapiens	P28799-2	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	OSMR	Homo sapiens	Q99650	Confocal	32807793
种属内	ATP5IF1	Q9UII2	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	HRAS	Homo sapiens	P01112	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	GSN	Homo sapiens	P06396	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	GSN	Homo sapiens	P06396	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	ATP5F1B	Homo sapiens	P06576	Anti Tag CoIP	33961781
种属内	ATP5IF1	Q9UII2	ATP5F1B	Homo sapiens	P06576	Crosslink	30021884
种属内	ATP5IF1	Q9UII2	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	ATP5IF1	Q9UII2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	A2M	Homo sapiens	P01023	Y2H Array	32814053
种属内	ATP5IF1	Q9UII2	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
种属内	ATP5IF1	Q9UII2	A2M	Homo sapiens	P01023	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Fallopian Tube Adenocarcinoma

Adenocarcinoma Of The Fallopian Tube

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01202	ATP5F1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01203	ATP5F1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01204	ATP5F1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01205	ATP5F1D Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01206	ATP5F1E Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01207	ATP5IF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01208	ATP5MC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ATP5IF1	MGD	MGI:1196457
Canis familiaris	ATP5IF1	VGNC	VGNC:38292
Felis catus	ATP5IF1	VGNC	VGNC:68724
Macaca mulatta	ATP5IF1	VGNC	VGNC:70192
Rattus norvegicus	ATP5IF1	RGD	RGD:2181

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