2. Gene
  3. IL32 - interleukin 32 Gene

IL32 - interleukin 32 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：白细胞介素 32

种属: Homo sapiens

同用名: NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma

基因 ID: 9235 | 基因类型: protein coding

关于 IL32

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,065,403-3,069,530 (from NCBI)

This gene has 35 transcripts (splice variants) and 8 orthologues. Broad expression in small intestine (RPKM 122.1), spleen (RPKM 121.0) and 22 other tissues.

功能概要

该基因编码细胞因子家族的一个成员。该蛋白质包含一个酪氨酸硫酸化位点、3 个潜在的 N-豆蔻酰化位点、多个假定的磷酸化位点和一个 RGD 细胞附着序列。在有丝分裂原激活 T 细胞或 IL-2 激活 NK 细胞后，该蛋白的表达增加。这种蛋白质诱导巨噬细胞产生 TNFalpha。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

IL32 基因产物(19)

mRNA Protein Name
NM_001012631.4 NP_001012649.1 interleukin-32 isoform B
NM_001012632.3 NP_001012650.1 interleukin-32 isoform B
NM_001012633.4 NP_001012651.1 interleukin-32 isoform A
NM_001012634.4 NP_001012652.1 interleukin-32 isoform C
NM_001012635.4 NP_001012653.1 interleukin-32 isoform C
NM_001012636.2 NP_001012654.1 interleukin-32 isoform D
NM_001012718.4 NP_001012736.1 interleukin-32 isoform B
NM_001308078.4 NP_001295007.1 interleukin-32 isoform E precursor
NM_001369587.3 NP_001356516.1 interleukin-32 isoform E precursor
NM_001369588.3 NP_001356517.1 interleukin-32 isoform E precursor
NM_001369589.3 NP_001356518.1 interleukin-32 isoform B
NM_001369590.3 NP_001356519.1 interleukin-32 isoform C
NM_001369591.3 NP_001356520.1 interleukin-32 isoform C
NM_001369592.3 NP_001356521.1 interleukin-32 isoform C
NM_001369593.3 NP_001356522.1 interleukin-32 isoform F
NM_001369595.3 NP_001356524.1 interleukin-32 isoform G
NM_001369596.3 NP_001356525.1 interleukin-32 isoform B
NM_001376923.1 NP_001363852.1 interleukin-32 isoform B
NM_004221.7 NP_004212.4 interleukin-32 isoform B
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16488976 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of negative regulation of viral life cycle IDA
IDA: 通过直接分析推断
23729669 GOA
acts upstream of positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23729669 GOA
acts upstream of or within positive regulation of gene expression IDA
IDA: 通过直接分析推断
23729669 GOA
acts upstream of or within positive regulation of type III interferon production IDA
IDA: 通过直接分析推断
23729669 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL32 蛋白结构

IL32

IL32: Interleukin 32 (114 - 211)

  • 0
  • 100
  • 200
  • 234 a.a.
蛋白主名 其他名称

interleukin-32

interleukin-32 eta

IL32 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IL32 P24001 RHBDD2 Homo sapiens Q6NTF9-3
Validated Y2H
32296183
种属内
IL32 P24001 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
种属内
IL32 P24001 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IL32 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73884 IL-32 alpha Protein, Human (HEK293, His) P24001-4/NP_001012651 (M1-K131) ≥95%
HY-P700124AF Animal-Free IL-32 alpha Protein, Human (His) P24001-4 (M1-K131) ≥95%

IL32 抗体

目录号 产品名 应用 反应物种
HY-P83166 IL-32 Antibody (YA2911) WB Human

关联疾病

疾病名称 别名
Microscopic Polyangiitis

Microscopic Polyarteritis

Mpa

Micropolyangiitis
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Granulomatosis With Polyangiitis

GPA

Wegener Granulomatosis

Wegener Granulomatosis, Formerly

Midline Granulomatosis

Wg, Formerly

Necrotizing Respiratory Granulomatosis

Wg

Wegeners Granulomatosis

Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06756 IL32 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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