PIWIL1 - piwi like RNA-mediated gene silencing 1 Gene

中文名称：piwi 样 RNA 介导的基因沉默 1

种属: Homo sapiens

同用名: HIWI; MIWI; PIWI; CT80.1

基因 ID: 9271 | 基因类型: protein coding

关于 PIWIL1

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,337,887-130,426,260 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 216 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 57.0).

功能概要

该基因编码 Argonaute 蛋白 PIWI 亚家族的成员，该蛋白包含 PAZ 和 Piwi 基序，在干细胞自我更新、RNA 沉默和不同生物体的翻译调节中发挥重要作用。编码的蛋白质可能作为种系和造血干细胞自我更新能力的内在调节剂发挥作用。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 7 月]

This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

PIWIL1 基因产物(2)

mRNA	Protein	Name
NM_001190971.2	NP_001177900.1	piwi-like protein 1 isoform 2
NM_004764.5	NP_004755.2	piwi-like protein 1 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables piRNA binding	IDA IDA: 通过直接分析推断	28552346	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	14749716	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in spermatid development	IMP IMP: 通过突变表型推断	28552346	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIWIL1 蛋白结构

GAGE

PAZ

Piwi

0
200
400
600
800
861 a.a.

蛋白主名

其他名称

piwi-like protein 1

piwi homolog

PIWIL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PIWIL1	Q96J94	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	PIWIL1	Q96J94	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	PIWIL1	Q96J94	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	PIWIL1	Q96J94	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	PIWIL1	Q96J94	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	PIWIL1	Q96J94	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Infertility

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1	HP1
Glycolic Aciduria	Alanine-Glyoxylate Aminotransferase Deficiency
Hepatic Agt Deficiency	Oxalosis I
Primary Hyperoxaluria, Type I	Serine:Pyruvate Aminotransferase Deficiency
Hyperoxaluria, Primary, Type 1	Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency
Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency	Serine Pyruvate Aminotransferase Deficiency
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Oxalosis 1
Hyperoxaluria Primary 1	Hyperoxaluria Primary Type I
Ph1	Primary Hyperoxaluria Type I
Oxalosis Type 1	2-Oxoglutarate Glyoxylate Carboligase Deficiency

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10584	PIWIL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PIWIL1	VGNC	VGNC:80463
Rattus norvegicus	PIWIL1	RGD	RGD:1306980
Bos taurus	PIWIL1	VGNC	VGNC:32927
Mus musculus	PIWIL1	MGD	MGI:1928897
Macaca mulatta	PIWIL1	VGNC	VGNC:81501
Canis familiaris	PIWIL1	VGNC	VGNC:44592

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