2. Gene
  3. IMP4 - IMP U3 small nucleolar ribonucleoprotein 4 Gene

IMP4 - IMP U3 small nucleolar ribonucleoprotein 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：IMP U3 小核仁核糖核蛋白 4

种属: Homo sapiens

同用名: BXDC4

基因 ID: 92856 | 基因类型: protein coding

关于 IMP4

Cytogenetic location: 2q21.1 Genomic coordinates (GRCh38): 2:130,342,897-130,347,967 (from NCBI)

This gene has 17 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 11.8), appendix (RPKM 9.3) and 25 other tissues.

功能概要

由该基因编码的蛋白质以及 IMP3 和 MPP10 是 60-80S U3 小核仁核糖核蛋白 (U3 snoRNP) 复合物的一部分。该复合物对于 pre-18S 核糖体 RNA 加工的早期切割步骤是必需的。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2016 年 2 月]

The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

IMP4 基因产物(16)

mRNA Protein Name
NM_001320304.2 NP_001307233.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform b
NM_001320305.2 NP_001307234.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform c
NM_001320306.2 NP_001307235.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform d
NM_001320307.2 NP_001307236.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform d
NM_001320309.2 NP_001307238.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001320310.2 NP_001307239.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001320311.2 NP_001307240.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform f
NM_001371725.1 NP_001358654.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform g
NM_001371726.1 NP_001358655.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform h
NM_001371728.1 NP_001358657.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform i
NM_001371730.1 NP_001358659.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform j
NM_001371731.1 NP_001358660.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001371732.1 NP_001358661.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001371733.1 NP_001358662.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_001371734.1 NP_001358663.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform e
NM_033416.3 NP_219484.1 U3 small nucleolar ribonucleoprotein protein IMP4 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12655004 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ribosomal small subunit biogenesis IDA
IDA: 通过直接分析推断
34516797 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Mpp10 complex IDA
IDA: 通过直接分析推断
12655004 GOA
part of Mpp10 complex IPI
IPI: 通过物理相互作用推断
12655004 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
12655004 GOA
part of preribosome IDA
IDA: 通过直接分析推断
12655004 GOA
part of small-subunit processome IDA
IDA: 通过直接分析推断
34516797 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IMP4 蛋白结构

Brix

Brix: Brix domain (87 - 258)

  • 0
  • 100
  • 200
  • 291 a.a.
蛋白主名 其他名称

U3 small nucleolar ribonucleoprotein protein IMP4

IMP4 homolog, U3 small nucleolar ribonucleoprotein

IMP4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IMP4 Q96G21 ZBTB7B Homo sapiens O15156-2
Y2H Array
32296183
种属内
IMP4 Q96G21 ZBTB7B Homo sapiens O15156-2
Y2H Prey Pooling
32296183
种属内
IMP4 Q96G21 MPHOSPH10 Homo sapiens O00566
Pull Down
12655004
种属内
IMP4 Q96G21 ZBTB7B Homo sapiens O15156
Validated Y2H
25416956
种属内
IMP4 Q96G21 ZBTB7B Homo sapiens O15156
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12826 IMB-XH1 Inhibitor ≥98.0% 否
HY-RS06794 IMP4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus IMP4 MGD MGI:106572
Felis catus IMP4 VGNC VGNC:62917
Bos taurus IMP4 VGNC VGNC:30183
Rattus norvegicus IMP4 RGD RGD:1308463
Macaca mulatta IMP4 VGNC VGNC:73689
Others IMP4 NCBI
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