1. Gene
  2. DMKN - dermokine Gene

DMKN - dermokine Gene

中文名称:皮肤因子

种属: Homo sapiens

同用名: UNQ729; ZD52F10

基因 ID: 93099 | 基因类型: protein coding

关于 DMKN

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,497,220-35,513,649 (from NCBI)

This gene has 68 transcripts (splice variants) and 64 orthologues. Biased expression in skin (RPKM 387.3) and esophagus (RPKM 47.0).

功能概要

该基因在炎症性疾病中被上调,并且首次被观察到在皮肤的分化层中表达。该基因最有趣的方面是启动子和终止子的不同使用,以生成具有独特细胞分布和结构域成分的亚型。已经为该基因鉴定了编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2010 年 6 月]

This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

DMKN 基因产物(16)

mRNA Protein Name
NM_001035516.4 NP_001030593.2 dermokine isoform 1 precursor
NM_001126056.3 NP_001119528.3 dermokine isoform 3 precursor
NM_001126057.3 NP_001119529.2 dermokine isoform 5 precursor
NM_001126058.3 NP_001119530.2 dermokine isoform 4 precursor
NM_001126059.4 NP_001119531.2 dermokine isoform 6
NM_001190347.2 NP_001177276.2 dermokine isoform 8 precursor
NM_001190348.2 NP_001177277.1 dermokine isoform 9 precursor
NM_001190349.2 NP_001177278.1 dermokine isoform 10 precursor
NM_001308380.2 NP_001295309.2 dermokine isoform 11
NM_001308383.2 NP_001295312.2 dermokine isoform 12
NM_001352328.2 NP_001339257.2 dermokine isoform 13
NM_001352329.2 NP_001339258.2 dermokine isoform 14
NM_001352330.2 NP_001339259.2 dermokine isoform 14
NM_001352331.2 NP_001339260.1 dermokine isoform 15
NM_001352332.2 NP_001339261.1 dermokine isoform 16
NM_033317.5 NP_201574.4 dermokine isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22735594 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

dermokine

epidermis-specific secreted protein SK30/SK89

DMKN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DMKN Q6E0U4 HSPA5 Homo sapiens P11021
Crosslink
22735594
种属内
DMKN Q6E0U4 HSPA5 Homo sapiens P11021
Competition Binding
22735594
种属内
DMKN Q6E0U4 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
种属内
DMKN Q6E0U4 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
种属内
DMKN Q6E0U4 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
种属内
DMKN Q6E0U4 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
种属内
DMKN Q6E0U4 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
种属内
DMKN Q6E0U4 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
种属内
DMKN Q6E0U4 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属内
DMKN Q6E0U4 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属内
DMKN Q6E0U4 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus DMKN VGNC VGNC:28107
Macaca mulatta DMKN VGNC VGNC:71903
Canis familiaris DMKN VGNC VGNC:40000
Rattus norvegicus DMKN RGD RGD:1561521
Mus musculus DMKN MGD MGI:1920962