2. Gene
  3. Gpnmb - glycoprotein (transmembrane) nmb Gene

Gpnmb - glycoprotein (transmembrane) nmb Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ipd; Dchil; DC-HIL

基因 ID: 93695 | 基因类型: protein coding

关于 Gpnmb

功能概要

Enables heparin binding activity and Integrin binding activity. Involved in several processes, including negative regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; and positive regulation of protein phosphorylation. Acts upstream of or within cell adhesion. Located in cytoplasmic vesicle. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; heart ventricle; and mesenchyme derived from neural crest. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb). [provided by Alliance of Genome Resources, Apr 2022]

Gpnmb 基因产物(1)

mRNA Protein Name
NM_053110.4 NP_444340.3 transmembrane glycoprotein NMB precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heparin binding IDA
IDA: 通过直接分析推断
11114299 MGI
enables integrin binding IDA
IDA: 通过直接分析推断
11114299 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell adhesion IDA
IDA: 通过直接分析推断
11114299 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
17475886 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
18036345 MGI
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
18036345 MGI
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
25010402 MGI
involved in regulation of tissue remodeling IMP
IMP: 通过突变表型推断
25010402 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
12638126 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
11114299 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transmembrane glycoprotein NMB

dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand

dendritic cell-associated transmembrane protein

iris pigment dispersion

osteoactivin

重组 Gpnmb 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77116 GPNMB/Osteoactivin Protein, Mouse (HEK293, His) Q99P91 (K23-N502) ≥95%

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-141604 Glembatumumab vedotin Inhibitor 99.90% Phase 2
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99205 Glembatumumab 99.69% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05648 GPNMB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gpnmb NCBI NCBI:10457
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