GPNMB - glycoprotein nmb Gene

中文名称：糖蛋白 nmb

种属: Homo sapiens

同用名: NMB; HGFIN; PLCA3

基因 ID: 10457 | 基因类型: protein coding

关于 GPNMB

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:23,246,775-23,275,108 (from NCBI)

This gene has 15 transcripts (splice variants), 205 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in skin (RPKM 225.4), gall bladder (RPKM 143.5) and 17 other tissues.

功能概要

由该基因编码的蛋白质是一种 I 型跨膜糖蛋白，它与黑素细胞特异性蛋白质 pMEL17 前体具有同源性。 GPNMB 在低转移性人黑色素瘤细胞系和异种移植物中表达，但在高转移性细胞系中不表达。 GPNMB 可能参与生长延迟和转移潜能的降低。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GPNMB 基因产物(2)

mRNA	Protein	Name
NM_001005340.2	NP_001005340.1	transmembrane glycoprotein NMB isoform a precursor
NM_002510.3	NP_002501.1	transmembrane glycoprotein NMB isoform b precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables heparin binding	IDA IDA: 通过直接分析推断	19350579	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12609765	GOA
enables receptor ligand activity	IMP IMP: 通过突变表型推断	19350579	GOA
enables syndecan binding	IPI IPI: 通过物理相互作用推断	19350579	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell-cell signaling	IMP IMP: 通过突变表型推断	19350579	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: 通过直接分析推断	19350579	GOA
involved in negative regulation of T cell activation	IMP IMP: 通过突变表型推断	19350579	GOA
involved in negative regulation of T cell proliferation	IDA IDA: 通过直接分析推断	19350579	GOA
involved in negative regulation of cytokine production	IDA IDA: 通过直接分析推断	19350579	GOA
involved in positive regulation of cell migration	IDA IDA: 通过直接分析推断	20711474	GOA
involved in positive regulation of protein autophosphorylation	IDA IDA: 通过直接分析推断	19350579	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: 通过直接分析推断	22891158	GOA
involved in regulation of tissue remodeling	IDA IDA: 通过直接分析推断	25010402	GOA
involved in signal transduction	IMP IMP: 通过突变表型推断	19350579	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane	IDA IDA: 通过直接分析推断	12609765	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPNMB 蛋白结构

PKD

0
100
200
300
400
500
572 a.a.

蛋白主名

其他名称

transmembrane glycoprotein NMB

glycoprotein (transmembrane) nmb

重组 GPNMB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70836	GPNMB/Osteoactivin Protein, Human (HEK293, His)	Q14956-1 (A22-P486)	≥95%
HY-P75950	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His)	Q14956-2 (A22-P474)	≥95%
HY-P75951	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc)	Q14956-2 (A22-P474)	≥95%

关联疾病

疾病名称

别名

Amyloidosis, Primary Localized Cutaneous, 3

Amyloidosis Cutis Dyschromica	PLCA3
Acd	Primary Localized Cutaneous Amyloidosis 3
Amyloidosis Cutis Dyschromia

Lichen Amyloidosis

Amyloid Lichen	Lichen Amyloidosus
Amyloidosis, Primary Cutaneous

Macular Amyloidosis

Amyloidosis, Macular

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Borderline Glaucoma

Preglaucoma

Ocular Pigment Dispersion With Or Without Glaucoma

Pigment Dispersion Syndrome	Glaucoma-Related Pigment Dispersion Syndrome
OPDG	Pds
Glaucoma, Pigment-Dispersion Type	Gpds1
Pigment-Dispersion Type Glaucoma	Pigment-Dispersion Syndrome
Glaucoma, Open-Angle

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis	Niemann-Pick Diseases
Lipoid Histiocytosis	Sphingomyelin Lipidosis
Sphingomyelinase Deficiency Disease	Lipid Histiocytosis
Neuronal Cholesterol Lipidosis	Neuronal Lipidosis
Npd	Sphingomyelinase Deficiency
Niemann-Pick Disease, Type A

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Takayasu Arteritis

Aortic Arch Syndrome	Pulseless Disease
Takayasu'S Arteritis	Idiopathic Aortitis
Young Female Arteritis	Aortic Arch Arteritis
Aortic Arches Defect	Aortic Arch Defects
Takayasu Disease	Aortic Arch Syndromes
Takayasu'S Disease	Ta
Obliterative Aortitis	Aortic Arch Giant-Cell Arteritis
Subclavian-Carotid Obstruction Syndrome	Idiopathic Medial Aortopathy And Arteriopathy
Takayasu Syndrome	Obliterative Brachiocephalic Arteritis Syndrome
Raeder-Harbitz Syndrome	Chronic Subclavian-Carotid Obstruction Syndrome
Giant-Cell Aortitis	Takayasu Aortitis
Nonspecific Aortoarteritis	Sclerosing Aortitis And Arteritis
Martorell 2 Syndrome	Young Female Aortic Arch Arteritis Syndrome

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Lymphangioleiomyomatosis

Lymphangiomyomatosis	LAM
Lung Lymphangioleiomyomatosis	Pulmonary Lymphangioleiomyomatosis
Lymphangioleiomyomatosis, Somatic	Lymphangio-Myomatosis

Iris Disease

Iris Diseases

Gaucher Disease, Type I

Glucocerebrosidase Deficiency	Acid Beta-Glucosidase Deficiency
Gba Deficiency	GD1
Gd I	Gaucher Disease, Noncerebral Juvenile
Gaucher Disease Type 1	Gaucher Disease Type I
Gaucher'S Disease Type I	Gaucher Disease
Gd 1	Non-Cerebral Juvenile Gaucher Disease
GD	Gaucher Disease 1
Adult Non-Neuronopathic Gaucher Disease	Noncerebral Juvenile Gaucher Disease
Type 1 Gaucher Disease	Gaucher Disease, Type 1

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-141604	Glembatumumab vedotin	Inhibitor	99.90%	Phase 2

目录号	产品名	作用方式	纯度	Phase
HY-P99205	Glembatumumab		99.69%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05648	GPNMB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GPNMB	MGD	MGI:1934765
Macaca mulatta	GPNMB	VGNC	VGNC:73123
Rattus norvegicus	GPNMB	RGD	RGD:71008
Felis catus	GPNMB	VGNC	VGNC:67413
Canis familiaris	GPNMB	VGNC	VGNC:41389
Bos taurus	GPNMB	VGNC	VGNC:29541
Others	GPNMB	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GPNMB - glycoprotein nmb Gene

关于 GPNMB

功能概要

GPNMB 基因产物(2)

GPNMB 蛋白结构

重组 GPNMB 蛋白

关联疾病

直系同源

热门区域

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GPNMB - glycoprotein nmb Gene

关于 GPNMB

功能概要

GPNMB 基因产物(2)

GPNMB 蛋白结构

重组 GPNMB 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z