2. Gene
  3. Hrg - histidine-rich glycoprotein Gene

Hrg - histidine-rich glycoprotein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hprg; Hrgp; D16jh2; D18020

基因 ID: 94175 | 基因类型: protein coding

关于 Hrg

功能概要

Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; positive regulation of blood vessel remodeling; and positive regulation of immune response to tumor cell. Acts upstream of or within several processes, including heme export; negative regulation of fibrinolysis; and regulation of transcription from RNA polymerase II promoter in response to iron. Located in endolysosome and phagolysosome membrane. Human ortholog(s) of this gene implicated in thrombophilia due to HRG deficiency and thrombosis. Orthologous to human HRG (histidine rich glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Hrg 基因产物(1)

mRNA Protein Name
NM_053176.2 NP_444406.2 histidine-rich glycoprotein precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15748999 MGI
enables serine-type endopeptidase inhibitor activity IMP
IMP: 通过突变表型推断
15869579 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
IMP: 通过突变表型推断
18797515 MGI
involved in defense response to fungus IMP
IMP: 通过突变表型推断
18797515 MGI
acts upstream of fibrinolysis IMP
IMP: 通过突变表型推断
15869579 MGI
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
22348394 MGI
involved in negative regulation of blood vessel endothelial cell migration IMP
IMP: 通过突变表型推断
22348394 MGI
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
22348394 MGI
acts upstream of or within negative regulation of fibrinolysis IMP
IMP: 通过突变表型推断
15869579 MGI
involved in positive regulation of blood vessel remodeling IMP
IMP: 通过突变表型推断
22348394 MGI
involved in positive regulation of immune response to tumor cell IMP
IMP: 通过突变表型推断
22348394 MGI
involved in regulation of blood coagulation IMP
IMP: 通过突变表型推断
15869579 MGI
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
22348394 MGI
involved in regulation of platelet activation IMP
IMP: 通过突变表型推断
15869579 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histidine-rich glycoprotein

histidine-proline-rich glycoprotein

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06358 HRG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hrg NCBI NCBI:3273
Canis familiaris Hrg NCBI NCBI:100683193
Rattus norvegicus Hrg NCBI NCBI:171016
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