2. Gene
  3. NCR1 - natural cytotoxicity triggering receptor 1 Gene

NCR1 - natural cytotoxicity triggering receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：天然细胞毒性触发受体 1

种属: Homo sapiens

同用名: LY94; CD335; NKP46; NK-p46

基因 ID: 9437 | 基因类型: protein coding

关于 NCR1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,898,198-54,938,208 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 86 orthologues and 25 paralogues. Biased expression in spleen (RPKM 1.6), bone marrow (RPKM 0.4) and 12 other tissues.

功能概要

预计参与细胞防御反应；调节自然杀伤细胞介导的细胞毒性；和信号转导。预计在对病毒的防御反应和病毒检测的上游或防御反应中起作用。预测位于细胞表面。预计成为 SWI/SNF 复合体的一部分。预计在质膜上有活性。获得性免疫缺陷综合征的生物标志物；肛门生殖器性病疣;丙型肝炎;和淋巴增生综合征。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in cellular defense response; regulation of natural killer cell mediated cytotoxicity; and signal transduction. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be part of SWI/SNF complex. Predicted to be active in plasma membrane. Biomarker of acquired immunodeficiency syndrome; anogenital venereal wart; hepatitis C; and lymphoproliferative syndrome. [provided by Alliance of Genome Resources, Apr 2022]

NCR1 基因产物(5)

mRNA Protein Name
NM_001145457.3 NP_001138929.2 natural cytotoxicity triggering receptor 1 isoform b precursor
NM_001145458.3 NP_001138930.2 natural cytotoxicity triggering receptor 1 isoform c precursor
NM_001242356.3 NP_001229285.1 natural cytotoxicity triggering receptor 1 isoform d precursor
NM_001242357.3 NP_001229286.1 natural cytotoxicity triggering receptor 1 isoform e precursor
NM_004829.7 NP_004820.2 natural cytotoxicity triggering receptor 1 isoform a precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17056548 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCR1 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (28 - 117)

Ig_3

Ig_3: Immunoglobulin domain (124 - 193)

  • 0
  • 100
  • 200
  • 304 a.a.
蛋白主名 其他名称

natural cytotoxicity triggering receptor 1

NK cell-activating receptor

重组 NCR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70174 NKp46/NCR1 Protein, Human (HEK293, Fc) O76036-6/AAH64806 (Q22-D254) ≥95%
HY-P77810 NKp46/NCR1 Protein, Human (HEK293, His) O76036-6/AAH64806 (Q22-D254) ≥95%
HY-P78008 NKp46/NCR1 Protein, Human (HEK293, mFc) O76036 (Q22-N255) ≥95%
HY-P78832 NKp46/NCR1 Protein, Human (Biotinylated, HEK293, His) O76036 (Q22-N254) ≥95%

关联疾病

疾病名称 别名
Gestational Trophoblastic Neoplasm

Hydatidiform Mole

Molar Pregnancy

Gestational Trophoblastic Neoplasia

Gestational Trophoblastic Tumor

Gtn

Gestational Trophoblastic Disease

Gestational Trophoblastic Neoplasms

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole Benign

Trophoblastic Disease

Trophoblastic Disease Nos

Trophoblastic Disorder

Vesicular Mole Nos

Vesicular Mole

Hydatidiform Mole Nos
Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole

Gestational Trophoblastic Disease

Complete Hydatidiform Mole

Hydm

HYDM1

Chm

Molar Pregnancy

Hydatidiform Mole, Complete

Hydatid Mole

Complete Molar Pregnancy

Mole, Hydatidiform, Recurrent, Type 1

Gestational Trophoblastic Neoplasms

Hydatidiform Mole, Recurrent, 2

Classical Hydatidiform Mole
Anogenital Venereal Wart

Genital Warts

Condylomata Acuminata

Anogenital Warts

Condyloma Acuminatum

Anogenital Human Papilloma Virus Infectious Disease

Genital Wart Virus Infectious Disease

Venereal Wart

Venereal Warts

Verrucae Anogenitales

Verrucae Genitales
Nk Cell Deficiency
Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest
Acquired Immunodeficiency Syndrome

Acquired Immune Deficiency Syndrome

AIDS

Acquired Immune Deficiency

Acquired Immunodeficiency

Acquired Immunodeficiency Due To Protein Loss
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections
Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To
Cd3zeta Deficiency
Bronchiectasis 1
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09098 NCR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NCR1 RGD RGD:621288
Mus musculus NCR1 MGD MGI:1336212
Bos taurus NCR1 VGNC VGNC:31926
Canis familiaris NCR1 VGNC VGNC:53740
Macaca mulatta NCR1 VGNC VGNC:75065
Macaca fascicularis NCR1 NCBI NCBI:102115479
Others NCR1 NCBI
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