CABP1 - calcium binding protein 1 Gene

中文名称：钙结合蛋白 1

种属: Homo sapiens

同用名: CALBRAIN; HCALB_BR

关于 CABP1

功能概要

钙结合蛋白是钙介导的细胞信号转导的重要组成部分。该基因编码的蛋白质属于钙结合蛋白亚家族，与钙调蛋白具有相似性。由该基因编码的蛋白质调节电压门控钙离子通道的门控。这种蛋白质抑制钙依赖性失活并支持钙依赖性促进含有电压依赖性 L 型钙通道亚基 alpha-1C 的离子通道。该蛋白还调节肌醇 1,4,5-三磷酸受体、P/Q 型电压门控钙通道和瞬时受体电位通道 TRPC5 的钙依赖性活性。该基因主要在视网膜和大脑中表达。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 7 月]

Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to Calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]