ADAMTS3 - ADAM metallopeptidase with thrombospondin type 1 motif 3 Gene

中文名称：具有 1 型血小板反应蛋白基序 3 的 ADAM 金属肽酶

种属: Homo sapiens

同用名: HKLLS3; ADAMTS-4

基因 ID: 9508 | 基因类型: protein coding

关于 ADAMTS3

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:72,280,969-72,569,221 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues, 25 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 1.4), ovary (RPKM 1.0) and 22 other tissues.

功能概要

该基因编码 ADAMTS (一种具有血小板反应蛋白基序的去整合素和金属蛋白酶) 蛋白家族的成员。该家族的成员共享几个不同的蛋白质模块，包括前肽区域、金属蛋白酶结构域、解整合素样结构域和 1 型血小板反应蛋白 (TS) 基序。这个家族的个别成员在 C 端 TS 基序的数量上有所不同，有些成员具有独特的 C 端结构域。编码的前原蛋白经过蛋白水解处理以产生成熟的蛋白酶。这种蛋白酶是前胶原氨基肽酶亚家族的成员，可能在关节软骨中 II 型纤维胶原蛋白的加工过程中发挥作用。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]

ADAMTS3 基因产物(1)

mRNA	Protein	Name
NM_014243.3	NP_055058.2	A disintegrin and metalloproteinase with thrombospondin motifs 3 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables endopeptidase activity	IDA IDA: 通过直接分析推断	24552833	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24552833	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in collagen biosynthetic process	IDA IDA: 通过直接分析推断	11408482	GOA
involved in positive regulation of vascular endothelial growth factor signaling pathway	IDA IDA: 通过直接分析推断	24552833	GOA
involved in protein processing	IDA IDA: 通过直接分析推断	11408482	GOA
involved in vascular endothelial growth factor production	IDA IDA: 通过直接分析推断	24552833	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	24552833	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAMTS3 蛋白结构

Pep_M12B_propep

Reprolysin

TSP_1

ADAM_spacer1

TSP_1

0
200
400
600
800
1000
1205 a.a.

蛋白主名

其他名称

A disintegrin and metalloproteinase with thrombospondin motifs 3

ADAM-TS 3

ADAMTS3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ADAMTS3	O15072	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
种属内	ADAMTS3	O15072	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
种属内	ADAMTS3	O15072	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hennekam Lymphangiectasia-Lymphedema Syndrome 3

HKLLS3

Hennekam Syndrome

Hennekam Lymphangiectasia Lymphedema Syndrome	Hennekam Lymphangiectasia-Lymphedema Syndrome
Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome	Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome
Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome	Lymphangiectasies And Lymphedema Hennekam Type
Generalized Lymphatic Dysplasia	Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome

Protein-Losing Enteropathy

Protein-Losing Enteropathies	Enteropathy, Exudative
Exudative Enteropathy	Ple - [Protein-Losing Enteropathy]

Spondyloepimetaphyseal Dysplasia, Missouri Type

Metaphyseal Anadysplasia 1	Semd, Missouri Type
Spondyloepimetaphyseal Dysplasia Type 2	SEMDM
Spondyloepimetaphyseal Dysplasia Missouri Type	Missouri Type Of Spondyloepimetaphyseal Dysplasia
Semd Missouri Type	Semd Type 2
MANDP1	Semd-Mo
Spondyloepimetaphyseal Dysplasia Type Missouri	Spondylometaepiphyseal Dysplasia Type Missouri
Anadysplasia, Metaphyseal, Type 1

Bone Deterioration Disease

Bone Structure Disease

Degenerative Disc Disease

Intervertebral Disc Degeneration	Cervical Disc Degenerative Disorder
Cervical Disc Degenerative Disease	Lumbar Disc Degeneration
Vertebral Disc Disease	Degeneration Of Lumbar Intervertebral Disc
Intervertebral Disc Disorder	Discogenic Disease

Cartilage Disease

Cartilage Diseases	Cartilage
Cartilage Disorder	Chondropathy
Cartilage Disorders

Spondylolisthesis

Slipped Vertebrae

Acquired Spondylolisthesis

Bone Inflammation Disease

Osteitis	Bone Inflammatory Disease
Inflammatory Disorder Of Bone

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00303	ADAMTS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ADAMTS3	VGNC	VGNC:69498
Felis catus	ADAMTS3	VGNC	VGNC:59594
Bos taurus	ADAMTS3	VGNC	VGNC:25626
Rattus norvegicus	ADAMTS3	RGD	RGD:1310750
Mus musculus	ADAMTS3	MGD	MGI:3045353
Others	ADAMTS3	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ADAMTS3 - ADAM metallopeptidase with thrombospondin type 1 motif 3 Gene

关于 ADAMTS3

功能概要

ADAMTS3 基因产物(1)

ADAMTS3 蛋白结构

ADAMTS3 蛋白互作信息

关联疾病

直系同源

热门区域

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ADAMTS3 - ADAM metallopeptidase with thrombospondin type 1 motif 3 Gene

关于 ADAMTS3

功能概要

ADAMTS3 基因产物(1)

ADAMTS3 蛋白结构

ADAMTS3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z