EEF1E1 - eukaryotic translation elongation factor 1 epsilon 1 Gene

中文名称：真核翻译延伸因子 1 epsilon 1

种属: Homo sapiens

同用名: P18; AIMP3

关于 EEF1E1

功能概要

该基因编码一种多功能蛋白，定位于细胞质和细胞核。在细胞质中，所编码的蛋白质是大分子氨酰-tRNA 合酶复合物的辅助成分。然而，它的小鼠同系物已被证明可以转移到细胞核以响应 DNA 损伤，并且它在 ATM/ATR 介导的 p53 激活中发挥积极作用。可变剪接导致多个转录本变体。通读转录也存在于该基因和邻近的下游 MUTED (静音同源物) 基因之间。已在 2 号染色体上鉴定出与 EEF1E1 相关的假基因。[RefSeq 提供，2010 年 12 月]

This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]