2. Gene
  3. CXCL14 - C-X-C motif chemokine ligand 14 Gene

CXCL14 - C-X-C motif chemokine ligand 14 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CXC 基序趋化因子配体 14

种属: Homo sapiens

同用名: KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14

基因 ID: 9547 | 基因类型: protein coding

关于 CXCL14

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,570,679-135,578,991 (from NCBI)

This gene has 2 transcripts (splice variants) and 194 orthologues. Biased expression in skin (RPKM 295.1), kidney (RPKM 161.0) and 13 other tissues.

功能概要

这种抗菌基因属于细胞因子基因家族，它编码参与免疫调节和炎症过程的分泌蛋白。该基因编码的蛋白质在结构上与细胞因子的 CXC (Cys-X-Cys) 亚家族相关。该亚家族成员的特征是两个半胱氨酸被一个氨基酸隔开。这种细胞因子对单核细胞显示出趋化活性，但对淋巴细胞、树突细胞、中性粒细胞或巨噬细胞没有趋化活性。已经暗示这种细胞因子参与单核细胞衍生的巨噬细胞的体内平衡而不是炎症。[RefSeq 提供，2014 年 9 月]

This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

CXCL14 基因产物(1)

mRNA Protein Name
NM_004887.5 NP_004878.3 C-X-C motif chemokine 14 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
12949249 GOA
involved in killing of cells of another organism IDA
IDA: 通过直接分析推断
12949249 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CXCL14 蛋白结构

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (35 - 97)

  • 0
  • 100
  • 111 a.a.
蛋白主名 其他名称

C-X-C motif chemokine 14

CXC chemokine in breast and kidney

CXCL14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CXCL14 O95715 PF4 Homo sapiens P02776
SPR
28381538
种属内
CXCL14 O95715 PF4 Homo sapiens P02776
Filter Binding
28381538
种属内
CXCL14 O95715 CCL5 Homo sapiens P13501
SPR
28381538
种属内
CXCL14 O95715 CCL5 Homo sapiens P13501
Filter Binding
28381538
种属内
CXCL14 O95715 CXCL11 Homo sapiens O14625
Filter Binding
28381538
种属内
CXCL14 O95715 CXCL9 Homo sapiens Q07325
Filter Binding
28381538
种属内
CXCL14 O95715 CXCL12 Homo sapiens P48061
Filter Binding
28381538
种属内
CXCL14 O95715 CXCL12 Homo sapiens P48061
SPR
28381538
种属内
CXCL14 O95715 TRIM23 Homo sapiens P36406
Y2H Array
25416956
种属内
CXCL14 O95715 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
种属内
CXCL14 O95715 TEX11 Homo sapiens Q8IYF3
Validated Y2H
25416956
种属内
CXCL14 O95715 CCL26 Homo sapiens Q9Y258
Filter Binding
28381538
种属内
CXCL14 O95715 CCL21 Homo sapiens O00585
Filter Binding
28381538
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CXCL14 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72683 CXCL14/BRAK Protein, Human O95715 (S35-E111) ≥95%
HY-P75315 CXCL14/BRAK Protein, Human (Biotinylated) O95715 (S35-E111) ≥95%

关联疾病

疾病名称 别名
Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix
Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03388 CXCL14 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CXCL14 VGNC VGNC:39748
Rattus norvegicus CXCL14 RGD RGD:1307406
Felis catus CXCL14 VGNC VGNC:61297
Macaca mulatta CXCL14 VGNC VGNC:71394
Bos taurus CXCL14 VGNC VGNC:27850
Mus musculus CXCL14 MGD MGI:1888514
Others CXCL14 NCBI
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