2. Gene
  3. MINPP1 - multiple inositol-polyphosphate phosphatase 1 Gene

MINPP1 - multiple inositol-polyphosphate phosphatase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：多重肌醇聚磷酸酶 1

种属: Homo sapiens

同用名: MIPP; PCH16; HIPER1; MINPP2

基因 ID: 9562 | 基因类型: protein coding

关于 MINPP1

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:87,504,893-87,553,461 (from NCBI)

This gene has 4 transcripts (splice variants), 301 orthologues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 5.4), adrenal (RPKM 4.7) and 25 other tissues.

功能概要

该基因编码多种肌醇多磷酸磷酸酶；一种从肌醇磷酸底物中去除 3-磷酸的酶。它是唯一已知的水解肌醇五磷酸和肌醇六磷酸的酶。该酶还将 2,3 双磷酸甘油酸 (2,3-BPG) 转化为 2-磷酸甘油酸；以前认为在糖酵解途径的 Rapoport-Luebering 分流中 2,3-BPG 合酶/2-磷酸酶 (BPGM) 所独有的活性。[RefSeq 提供，2009 年 9 月]

This gene encodes multiple inositol polyphosphate phosphatase; an Enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only Enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This Enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

MINPP1 基因产物(3)

mRNA Protein Name
NM_001178117.2 NP_001171588.1 multiple inositol polyphosphate phosphatase 1 isoform 2 precursor
NM_001178118.2 NP_001171589.1 multiple inositol polyphosphate phosphatase 1 isoform 3
NM_004897.5 NP_004888.2 multiple inositol polyphosphate phosphatase 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables bisphosphoglycerate 3-phosphatase activity IDA
IDA: 通过直接分析推断
18413611 GOA
enables inositol bisphosphate phosphatase activity IDA
IDA: 通过直接分析推断
36589890 GOA
enables inositol pentakisphosphate phosphatase activity IMP
IMP: 通过突变表型推断
33257696 GOA
enables inositol trisphosphate phosphatase activity IDA
IDA: 通过直接分析推断
36589890 GOA
enables inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity IDA
IDA: 通过直接分析推断
36589890 GOA
NOT enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IDA
IDA: 通过直接分析推断
36589890 GOA
enables inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity IDA
IDA: 通过直接分析推断
36589890 GOA
enables inositol-hexakisphosphate phosphatase activity IDA
IDA: 通过直接分析推断
36589890 GOA
enables inositol-hexakisphosphate phosphatase activity IMP
IMP: 通过突变表型推断
33257696 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of intracellular monoatomic cation homeostasis IMP
IMP: 通过突变表型推断
33257696 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IMP
IMP: 通过突变表型推断
33257696 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MINPP1 蛋白结构

His_Phos_2

His_Phos_2: Histidine phosphatase superfamily (branch 2) (82 - 439)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 487 a.a.
蛋白主名 其他名称

multiple inositol polyphosphate phosphatase 1

2,3-BPG phosphatase

重组 MINPP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70937 MINPP1 Protein, Human (HEK293, His) Q9UNW1 (S31-L487) ≥95%
HY-P71854 MINPP1 Protein, Human (P.pastoris, His) Q9UNW1 (31S-487L) ≥95%

关联疾病

疾病名称 别名
Pontocerebellar Hypoplasia, Type 16

PCH16

Pontocerebellar Hypoplasia Type 16

Pontocerebellar Hypoplasia 16

Doid:0112333
Thyroid Cancer, Nonmedullary, 2

Thyroid Carcinoma, Follicular

Follicular Thyroid Carcinoma

NMTC2

Thyroid Cancer, Follicular

Thyroid Carcinoma, Follicular, Somatic

Ftc

Thyroid Cancer, Non-Medullary, 2

Thyroid Follicular Carcinoma

Follicular Thyroid Cancer

Cancer, Thyroid, Nonmedullary, Type 2

Thyroid Gland Adenocarcinoma

Follicular Carcinoma Of Unspecified Site

Moderately Differentiated Follicular Carcinoma Of Thyroid Gland

Pure Follicle Carcinoma Of Thyroid Gland

Pure Follicle Follicular Carcinoma Of Unspecified Site

Pure Follicular Carcinoma Of Thyroid Gland

Trabecular Follicular Carcinoma Of Thyroid Gland

Trabecular Follicular Carcinoma Of Unspecified Site

Well Differentiated Follicular Carcinoma Of Unspecified Site

Well Differentiated Follicular Carcinoma Of Thyroid Gland
Pontocerebellar Hypoplasia, Type 7

Pontocerebellar Hypoplasia Type 7

PCH7

Pontocerebellar Hypoplasia-46,Xy Disorder Of Sex Development Syndrome

Pontocerebellar Hypoplasia 7

Hypoplasia, Pontocerebellar, Type 7
Non-Syndromic Pontocerebellar Hypoplasia

Pontoneocerebellar Hypoplasia

Pch

Pontoneocerebellar Atrophy
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
Familial Papillary Or Follicular Thyroid Carcinoma

Fnmtc

Familial Pure Nonmedullary Thyroid Carcinoma

Familial Nonmedullary Thyroid Gland Carcinoma
Lipoid Proteinosis Of Urbach And Wiethe

Lipoid Proteinosis

Urbach-Wiethe Disease

Hyalinosis Cutis Et Mucosae

Lipid Proteinosis

Lipoproteinosis

Urbach Wiethe Disease

Lipoglycoproteinosis

Lipoidosis Cutis Et Mucosae

Lipoidproteinosis

Urbach-Wiethe Lipoid Proteinosis

Urbach-Wiethe Syndrome

LIP

Proteinosis Lipoid
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08457 MINPP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MINPP1 VGNC VGNC:74871
Canis familiaris MINPP1 VGNC VGNC:59061
Bos taurus MINPP1 VGNC VGNC:31480
Mus musculus MINPP1 MGD MGI:1336159
Rattus norvegicus MINPP1 RGD RGD:3089
Others MINPP1 NCBI
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