1. Gene
  2. FEZ2 - fasciculation and elongation protein zeta 2 Gene

FEZ2 - fasciculation and elongation protein zeta 2 Gene

中文名称:束缚和伸长蛋白 zeta 2

种属: Homo sapiens

同用名: HUM3CL

基因 ID: 9637 | 基因类型: protein coding

关于 FEZ2

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:36,552,258-36,598,168 (from NCBI)

This gene has 16 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 32.7), brain (RPKM 29.1) and 24 other tissues.

功能概要

该基因是秀丽隐杆线虫 unc-76 基因的直向同源基因,它是正常轴突捆绑和轴突束内伸长所必需的。其他直系同源物包括编码 zygin II 的大鼠基因,它可以与突触结合蛋白结合。[RefSeq 提供,2008 年 7 月]

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]

FEZ2 基因产物(2)

mRNA Protein Name
NM_001042548.2 NP_001036013.1 fasciculation and elongation protein zeta-2 isoform 2
NM_005102.3 NP_005093.2 fasciculation and elongation protein zeta-2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14690447 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
25495476 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FEZ2 蛋白结构

FEZ

FEZ: FEZ-like protein (49 - 289)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
蛋白主名 其他名称

fasciculation and elongation protein zeta-2

pre-T/NK cell associated protein (3Cl)

FEZ2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FEZ2 Q9UHY8 SCOC Homo sapiens Q9UIL1-3
Validated Y2H
32296183
种属内
FEZ2 Q9UHY8 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
种属内
FEZ2 Q9UHY8 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
种属内
FEZ2 Q9UHY8 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
种属内
FEZ2 Q9UHY8 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
种属内
FEZ2 Q9UHY8 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
种属内
FEZ2 Q9UHY8 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
种属内
FEZ2 Q9UHY8 PSEN1 Homo sapiens P49768-2
Validated Y2H
32814053
种属内
FEZ2 Q9UHY8 PSEN1 Homo sapiens P49768-2
Y2H Array
32814053
种属内
FEZ2 Q9UHY8 PSEN1 Homo sapiens P49768-2
Y2H Pooling
32814053
种属内
FEZ2 Q9UHY8 APP Homo sapiens P05067-2
Validated Y2H
32814053
种属内
FEZ2 Q9UHY8 APP Homo sapiens P05067-2
Y2H Array
32814053
种属内
FEZ2 Q9UHY8 APP Homo sapiens P05067-2
Y2H Pooling
32814053
种属内
FEZ2 Q9UHY8 DCTN1 Homo sapiens Q14203-5
Validated Y2H
32814053
种属内
FEZ2 Q9UHY8 DCTN1 Homo sapiens Q14203-5
Y2H Array
32814053
种属内
FEZ2 Q9UHY8 DCTN1 Homo sapiens Q14203-5
Y2H Pooling
32814053
种属内
FEZ2 Q9UHY8 PINK1 Homo sapiens Q9BXM7
Y2H Array
32814053
种属内
FEZ2 Q9UHY8 PINK1 Homo sapiens Q9BXM7
Validated Y2H
32814053
种属内
FEZ2 Q9UHY8 PINK1 Homo sapiens Q9BXM7
Y2H Pooling
32814053
种属内
FEZ2 Q9UHY8 NEK1 Homo sapiens Q96PY6
Pull Down
14690447
种属内
FEZ2 Q9UHY8 NEK1 Homo sapiens Q96PY6
Y2H
14690447
种属内
FEZ2 Q9UHY8 SMN1 Homo sapiens Q16637
Y2H Array
32814053
种属内
FEZ2 Q9UHY8 SMN1 Homo sapiens Q16637
Validated Y2H
32814053
种属内
FEZ2 Q9UHY8 SMN1 Homo sapiens Q16637
Y2H Pooling
32814053
种属内
FEZ2 Q9UHY8 ZDHHC17 Homo sapiens Q8IUH5
Lumier
24705354
种属内
FEZ2 Q9UHY8 ZDHHC17 Homo sapiens Q8IUH5
Y2H Array
24705354
种属内
FEZ2 Q9UHY8 TTR Homo sapiens P02766
Validated Y2H
32814053
种属内
FEZ2 Q9UHY8 TTR Homo sapiens P02766
Y2H Pooling
32814053
种属内
FEZ2 Q9UHY8 TTR Homo sapiens P02766
Y2H Array
32814053
种属内
FEZ2 Q9UHY8 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
FEZ2 Q9UHY8 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
FEZ2 Q9UHY8 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
FEZ2 Q9UHY8 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
种属内
FEZ2 Q9UHY8 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
种属内
FEZ2 Q9UHY8 PRPS1 Homo sapiens P60891
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Martsolf Syndrome 1

Martsolf Syndrome

Cataract-Intellectual Disability-Hypogonadism Syndrome

MARTS1

Marts

Cataract-Mental Retardation-Hypogonadism

Martsolf

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus FEZ2 MGD MGI:2675856
Rattus norvegicus FEZ2 RGD RGD:619709
Bos taurus FEZ2 VGNC VGNC:28958
Macaca mulatta FEZ2 VGNC VGNC:72640
Canis familiaris FEZ2 VGNC VGNC:40828
Felis catus FEZ2 VGNC VGNC:109565