FEZ1 - fasciculation and elongation protein zeta 1 Gene

中文名称：束缚和伸长蛋白 zeta 1

种属: Homo sapiens

同用名: UNC-76

基因 ID: 9638 | 基因类型: protein coding

关于 FEZ1

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,442,881-125,496,265 (from NCBI)

This gene has 17 transcripts (splice variants), 219 orthologues and 1 paralogue. Biased expression in brain (RPKM 74.3), urinary bladder (RPKM 9.7) and 4 other tissues.

功能概要

该基因是秀丽隐杆线虫 unc-76 基因的直向同源基因，它是正常轴突捆绑和轴突束内伸长所必需的。该基因在秀丽隐杆线虫 unc-76 突变体中的表达可以恢复突变体的部分运动和轴突肌束震颤，表明它也在轴突生长中发挥作用。基因产物的 N 端一半呈强酸性。已经描述了编码该蛋白质的不同同种型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

FEZ1 基因产物(2)

mRNA	Protein	Name
NM_005103.5	NP_005094.1	fasciculation and elongation protein zeta-1 isoform 1
NM_022549.4	NP_072043.1	fasciculation and elongation protein zeta-1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14690447	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of autophagosome assembly	IMP IMP: 通过突变表型推断	25495476	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	25495476	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FEZ1 蛋白结构

FEZ

0
100
200
300
392 a.a.

蛋白主名

其他名称

fasciculation and elongation protein zeta-1

zygin I

FEZ1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	FEZ1	Q99689	SCOC	Homo sapiens	Q9UIL1	Anti Tag CoIP	33961781
Intra	FEZ1	Q99689	NEK1	Homo sapiens	Q96PY6	Pull Down	14690447
Intra	FEZ1	Q99689	NEK1	Homo sapiens	Q96PY6	Y2H	14690447
Intra	FEZ1	Q99689	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	FEZ1	Q99689	HTT	Homo sapiens	P42858	Anti Tag CoIP	28514442
Intra	FEZ1	Q99689	HTT	Homo sapiens	P42858	Pull Down	15383276
Intra	FEZ1	Q99689	CEP126	Homo sapiens	Q9P2H0	Y2H	15383276
Intra	FEZ1	Q99689	TXNDC9	Homo sapiens	O14530	Anti Tag CoIP	16169070

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lissencephaly 1

LIS1	Classic Lissencephaly
Ils	Subcortical Laminar Heterotopia
Lissencephaly Due To Lis1 Mutation	Lissencephaly Sequence, Isolated
Lissencephaly, Classic	Pafah1b1-Related Lissencephaly
Classical Lissencephaly	Lissencephaly Type 1
Lissencephaly-1	Subcortical Band Heterotopia
Double Cortex	Lissencephaly Classic
Lissencephaly Sequence Isolated	Isolated Lissencephaly Sequence
Type 1 Lissencephaly	Lissencephaly Syndrome Type 1
SBH	Sclh
Lissencephaly, Type 1	Type I Lissencephaly

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04870	FEZ1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	FEZ1	VGNC	VGNC:72639
Mus musculus	FEZ1	MGD	MGI:2670976
Rattus norvegicus	FEZ1	RGD	RGD:619708
Felis catus	FEZ1	VGNC	VGNC:62234
Canis familiaris	FEZ1	VGNC	VGNC:40827
Bos taurus	FEZ1	VGNC	VGNC:28957

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