2. Gene
  3. SAFB2 - scaffold attachment factor B2 Gene

SAFB2 - scaffold attachment factor B2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：支架附着因子 B2

种属: Homo sapiens

基因 ID: 9667 | 基因类型: protein coding

关于 SAFB2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,586,999-5,622,776 (from NCBI)

This gene has 11 transcripts (splice variants), 99 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 19.8), spleen (RPKM 18.1) and 25 other tissues.

功能概要

由该基因编码的蛋白质及其旁系同源物 (支架附着因子 B1) 是雌激素受体 α 的阻遏物。编码的蛋白质结合支架/基质附着区 (S/MAR) DNA，并参与细胞周期调节、细胞凋亡、分化、应激反应和免疫基因调节。[RefSeq 提供，2016 年 5 月]

The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of Estrogen Receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, Apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016]

SAFB2 基因产物(1)

mRNA Protein Name
NM_014649.3 NP_055464.1 scaffold attachment factor B2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19674106 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12660241 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SAFB2 蛋白结构

SAP

SAP: SAP domain (30 - 63)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (409 - 478)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 953 a.a.
蛋白主名 其他名称

scaffold attachment factor B2

SAFB2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SAFB2 Q14151 SORBS3 Homo sapiens O60504-2
Anti Bait CoIP
12660241
Intra SAFB2 Q14151 SORBS3 Homo sapiens O60504-2
Confocal
12660241
Intra SAFB2 Q14151 SAFB Homo sapiens Q15424
Anti Tag CoIP
12660241
Intra SAFB2 Q14151 TRIP6 Homo sapiens Q15654
Anti Tag CoIP
33961781
Intra SAFB2 Q14151 SAFB2 Homo sapiens Q14151
Pull Down
19674106
Intra SAFB2 Q14151 ESR1 Homo sapiens P03372
Pull Down
12660241
Intra SAFB2 Q14151 DHPS Homo sapiens P49366
Anti Tag CoIP
33961781
Intra SAFB2 Q14151 DHPS Homo sapiens P49366
Anti Tag CoIP
28514442
Intra SAFB2 Q14151 SAFB2 Homo sapiens Q14151
Anti Tag CoIP
19674106
Intra SAFB2 Q14151 TRIP6 Homo sapiens Q15654
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12414 SAFB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SAFB2 VGNC VGNC:77080
Felis catus SAFB2 VGNC VGNC:64855
Rattus norvegicus SAFB2 RGD RGD:1588577
Bos taurus SAFB2 VGNC VGNC:34262
Canis familiaris SAFB2 VGNC VGNC:45845
Mus musculus SAFB2 MGD MGI:2146808
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