1. Gene
  2. SAFB - scaffold attachment factor B Gene

SAFB - scaffold attachment factor B Gene

中文名称:支架附着因子 B

种属: Homo sapiens

同用名: HAP; HET; SAF-B; SAFB1; SAB-B1; SAF-B1

基因 ID: 6294 | 基因类型: protein coding

关于 SAFB

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,623,083-5,668,478 (from NCBI)

This gene has 14 transcripts (splice variants), 235 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 29.9), testis (RPKM 26.5) and 25 other tissues.

功能概要

该基因编码一种 DNA 结合蛋白,该蛋白对支架或基质附着区域 DNA 元件 (S/MAR DNA) 具有高度特异性。这种蛋白质被认为与将染色质环的碱基连接到核基质有关,但关于这种蛋白质是染色质的成分还是核基质蛋白,存在相互矛盾的证据。支架附着因子是特异性结合 S/MAR 的核基质蛋白 (NMP) 的特定子集。编码的蛋白质被认为是在活跃转录基因附近组装“转录体复合物”的分子基础。它参与热休克蛋白 27 转录的调节,可作为雌激素受体共阻遏物,是乳腺肿瘤发生的候选物。该基因与具有相同功能的相似基因并列排列。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2011 年 1 月]

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an Estrogen Receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

SAFB 基因产物(6)

mRNA Protein Name
NM_001201338.2 NP_001188267.1 scaffold attachment factor B1 isoform 1
NM_001201339.2 NP_001188268.1 scaffold attachment factor B1 isoform 2
NM_001201340.2 NP_001188269.1 scaffold attachment factor B1 isoform 4
NM_001320571.2 NP_001307500.1 scaffold attachment factor B1 isoform 5
NM_001320572.2 NP_001307501.1 scaffold attachment factor B1 isoform 6
NM_002967.4 NP_002958.2 scaffold attachment factor B1 isoform 3
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12660241 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
22693546 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SAFB 蛋白结构

SAP

SAP: SAP domain (31 - 65)

(409 - 477)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 915 a.a.
蛋白主名 其他名称

scaffold attachment factor B1

HSP27 ERE-TATA-binding protein

SAFB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SAFB Q15424 SAFB2 Homo sapiens Q14151
Anti Tag CoIP
12660241
Intra SAFB Q15424 SAFB2 Homo sapiens Q14151
Y2H
12660241
Intra SAFB Q15424 TP53 Homo sapiens P04637
Anti Bait CoIP
21130767
Intra SAFB Q15424 TP53 Homo sapiens P04637
IF
21130767
Intra SAFB Q15424 SRPK1 Homo sapiens Q96SB4-2
Anti Tag CoIP
19674106
Intra SAFB Q15424 SRPK1 Homo sapiens Q96SB4-2
Pull Down
19674106
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Denys-Drash Syndrome

Drash Syndrome

DDS

Nephropathy, Wilms Tumor, And Genital Anomalies

Wilms Tumor And Pseudohermaphroditism

Wilms Tumor And Pseudo- Or True Hermaphroditism

Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor

Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor

Wilms Tumor-Dsd Syndrome

Wilms Tumor-Disorder Of Sex Development Syndrome

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SAFB VGNC VGNC:76964
Felis catus SAFB VGNC VGNC:64854
Canis familiaris SAFB VGNC VGNC:45844
Rattus norvegicus SAFB RGD RGD:620613
Mus musculus SAFB MGD MGI:2146974
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