2. Gene
  3. TGS1 - trimethylguanosine synthase 1 Gene

TGS1 - trimethylguanosine synthase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：三甲基鸟苷合酶 1

种属: Homo sapiens

同用名: PIMT; PIPMT; NCOA6IP

基因 ID: 96764 | 基因类型: protein coding

关于 TGS1

Cytogenetic location: 8q12.1 Genomic coordinates (GRCh38): 8:55,773,446-55,826,445 (from NCBI)

This gene has 3 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in lymph node (RPKM 6.7), appendix (RPKM 5.1) and 25 other tissues.

功能概要

启用 RNA 三甲基鸟苷合酶活性。参与 7-甲基鸟苷帽高甲基化。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA trimethylguanosine synthase activity. Involved in 7-methylguanosine cap hypermethylation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TGS1 基因产物(3)

mRNA Protein Name
NM_001317902.2 NP_001304831.1 trimethylguanosine synthase isoform 2
NM_001363184.2 NP_001350113.1 trimethylguanosine synthase isoform 3
NM_024831.8 NP_079107.6 trimethylguanosine synthase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA cap trimethylguanosine synthase activity IDA
IDA: 通过直接分析推断
16687569 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21522132 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 7-methylguanosine cap hypermethylation IDA
IDA: 通过直接分析推断
16687569 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12943661 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12943661 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TGS1 蛋白结构

Methyltransf_15

Methyltransf_15: RNA cap guanine-N2 methyltransferase (692 - 844)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 853 a.a.
蛋白主名 其他名称

trimethylguanosine synthase

CLL-associated antigen KW-2

重组 TGS1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71608 TGS1 Protein, Human (His-SUMO) Q96RS0 (713M-853T) ≥95%

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14466 TGS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TGS1 VGNC VGNC:35815
Felis catus TGS1 VGNC VGNC:66146
Macaca mulatta TGS1 VGNC VGNC:78404
Canis familiaris TGS1 VGNC VGNC:47321
Rattus norvegicus TGS1 RGD RGD:1309953
Mus musculus TGS1 MGD MGI:2151797
Others TGS1 NCBI
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