NOS1AP - nitric oxide synthase 1 adaptor protein Gene

中文名称：一氧化氮合酶 1 衔接蛋白

种属: Homo sapiens

同用名: CAPON; NPHS22; 6330408P19Rik

基因 ID: 9722 | 基因类型: protein coding

关于 NOS1AP

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:162,069,691-162,370,475 (from NCBI)

This gene has 6 transcripts (splice variants), 220 orthologues, 11 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 5.4), adrenal (RPKM 1.1) and 11 other tissues.

功能概要

该基因编码一种与信号分子神经元一氧化氮合酶 (nNOS) 结合的胞质蛋白。该蛋白具有介导与 nNOS 相互作用的 C 末端 PDZ 结合结构域和与小单体 G 蛋白 Dexras1 结合的 N 末端磷酸酪氨酸结合 (PTB) 结构域。对小鼠和大鼠相关蛋白的研究表明，该蛋白作为衔接蛋白发挥作用，将 nNOS 连接到特定靶标，例如 Dexras1 和突触蛋白。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 9 月]

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

NOS1AP 基因产物(3)

mRNA	Protein	Name
NM_001126060.2	NP_001119532.2	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 2
NM_001164757.2	NP_001158229.1	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 3
NM_014697.3	NP_055512.1	carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in postsynaptic actin cytoskeleton organization	IDA IDA: 通过直接分析推断	26869880	GOA
involved in postsynaptic actin cytoskeleton organization	IEP IEP: 通过表达模式推断	26869880	GOA
involved in postsynaptic actin cytoskeleton organization	IMP IMP: 通过突变表型推断	26869880	GOA
involved in regulation of heart rate by chemical signal	IMP IMP: 通过突变表型推断	19247217	GOA
involved in regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: 通过突变表型推断	19247217	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	26869880	GOA
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	26869880	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOS1AP 蛋白结构

PID

0
100
200
300
400
506 a.a.

蛋白主名

其他名称

carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)

关联疾病

疾病名称

别名

Nephrotic Syndrome, Type 22

NPHS22	Nephrotic Syndrome Type 22
Nephrotic Syndrome 22

Paranoid Personality Disorder

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Personality Disorder

Personality Disorders	Character Disorder
Personality	Specific Personality Disorders
Enduring Personality Change After Psychiatric Illness

Acute Ethmoiditis

Acute Ethmoidal Sinusitis	Acute Ethmoid Sinusitis
Ethmoidal Sinus - Acute

Short Qt Syndrome

Sqts	Familial Short Qt Syndrome

Long Qt Syndrome 13

LQT13

Qt Syndrome, Long, Type 13

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Long Qt Syndrome 2

LQT2	Long Qt Syndrome, Acquired, Reduced Susceptibility To
Long Qt Syndrome 1/2	Long Qt Syndrome 2/3
Long Qt Syndrome 2/5	Long Qt Syndrome 2, Acquired, Susceptibility To
Long Qt Syndrome, Acquired, Reduced	Long Qt Syndrome Type 2
Long Qt Syndrome 2/9	Lqt1/2
Lqt2/3	Lqt2/5
Lqt2/9	Susceptibility To Acquired Long Qt Syndrome 2
Long Qt Syndrome-2	Qt Syndrome, Long, Type 2
Long Qt Syndrome 1-2	Long Qt Syndrome 2-3
Long Qt Syndrome 2-5	Long Qt Syndrome 9

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Long Qt Syndrome 3

LQT3	Long Qt Syndrome Type 3
Long Qt Syndrome-3	Qt Syndrome, Long, Type 3

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Catecholaminergic Polymorphic Ventricular Tachycardia

Cpvt	Catecholamine-Induced Polymorphic Ventricular Tachycardia
Familial Polymorphic Ventricular Tachycardia	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Stress-Induced Polymorphic Ventricular Tachycardia
Bidirectional Tachycardia Induced By Catecholamine	Double Tachycardia Induced By Catecholamines
Polymorphic Catecholergic Ventricular Tachycardia	Syncopal Paroxysmal Tachycardia
Bidirectional Tachycardia Induced By Catecholamines	Fpvt
Bidirectional Ventricular Tachycardia Induced By Catecholamine	Polymorphic Ventricular Tachycardia Induced By Catecholamines
Ventricular Tachycardia, Catecholaminergic Polymorphic	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
Familial Ventricular Tachycardia	Multifocal Pvcs
Multifocal Premature Ventricular Beats

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-124996	(Rac)-ZLc-002	Inhibitor	98.96%	否
HY-RS09436	NOS1AP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NOS1AP	VGNC	VGNC:55636
Rattus norvegicus	NOS1AP	RGD	RGD:620106
Mus musculus	NOS1AP	MGD	MGI:1917979

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NOS1AP - nitric oxide synthase 1 adaptor protein Gene

关于 NOS1AP

功能概要

NOS1AP 基因产物(3)

NOS1AP 蛋白结构

关联疾病

直系同源

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NOS1AP - nitric oxide synthase 1 adaptor protein Gene

关于 NOS1AP

功能概要

NOS1AP 基因产物(3)

NOS1AP 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z