NKAP - NFKB activating protein Gene

中文名称：NFκB 活化蛋白

种属: Homo sapiens

同用名: MRXSHD

关于 NKAP

功能概要

该基因编码一种参与普遍存在的转录因子 NF-kappaB 激活的蛋白质。该蛋白与组蛋白脱乙酰酶 HDAC3 和 Notch 辅阻遏物复合物相关，因此它充当 Notch 靶基因的转录阻遏物。它也是 alphabeta T 细胞发育所必需的。已在 X 染色体上鉴定出相关的假基因，而具有完整 CDS 且可能具有功能的相关且无内含子的逆转录位于 6 号染色体上。[RefSeq 提供，2010 年 5 月]

This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]