SART3 - spliceosome associated factor 3, U4/U6 recycling protein Gene

中文名称：剪接体相关因子 3，U4/U6 回收蛋白

种属: Homo sapiens

同用名: P100; p110; DSAP1; TIP110; p110(nrb); RP11-13G14

关于 SART3

功能概要

该基因编码的蛋白质是一种 RNA 结合核蛋白，是一种肿瘤排斥抗原。该抗原具有能够在癌症患者中诱导 HLA-A24 限制性和肿瘤特异性细胞毒性 T 淋巴细胞的肿瘤表位，可用于特异性免疫治疗。该基因产物被发现是 HIV-1 基因表达和病毒复制的重要细胞因子。它还在剪接体循环的回收阶段与 U6 和 U4/U6 snRNP 短暂结合。这种编码的蛋白质被认为参与了 mRNA 剪接的调节。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in Cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]