1. Gene
  2. MRPL19 - mitochondrial ribosomal protein L19 Gene

MRPL19 - mitochondrial ribosomal protein L19 Gene

中文名称:线粒体核糖体蛋白 L19

种属: Homo sapiens

同用名: RLX1; L19mt; MRPL15; RPML15; MRP-L15; MRP-L19

基因 ID: 9801 | 基因类型: protein coding

关于 MRPL19

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:75,646,783-75,662,206 (from NCBI)

This gene has 7 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in thyroid (RPKM 7.4), kidney (RPKM 7.1) and 25 other tissues.

功能概要

哺乳动物线粒体核糖体蛋白由核基因编码,有助于线粒体内的蛋白质合成。线粒体核糖体 (线粒体核糖体) 由一个小的 28S 亚基和一个大的 39S 亚基组成。与原核核糖体相比,它们估计有 75% 的蛋白质与 rRNA 组成,而原核核糖体的比例是相反的。哺乳动物 线粒体核糖体 和原核核糖体之间的另一个区别是后者包含 5S rRNA。在不同的物种中,构成核糖体的蛋白质在序列上有很大差异,有时在生化特性上也有很大差异,这使得序列同源性难以识别。该基因编码一个 39S 亚基蛋白。[RefSeq 提供,2008 年 7 月]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

MRPL19 基因产物(1)

mRNA Protein Name
NM_014763.4 NP_055578.2 39S ribosomal protein L19, mitochondrial
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
29513927 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mitochondrial large ribosomal subunit IDA
IDA: 通过直接分析推断
25278503 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
28892042 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10942595 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MRPL19 蛋白结构

Ribosomal_L19

Ribosomal_L19: Ribosomal protein L19 (102 - 192)

  • 0
  • 100
  • 200
  • 292 a.a.
蛋白主名 其他名称

39S ribosomal protein L19, mitochondrial

39S ribosomal protein L15, mitochondrial

MRPL19 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MRPL19 P49406 LRRK2 Homo sapiens Q5S007
Protein Array
29513927
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dyslexia
Reading Disorder

Specific Reading Disorder

Reading

Dyslexia

Developmental Reading Disorder

Specific Language Impairment

Language Impairment, Specific

Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus MRPL19 MGD MGI:1926274
Rattus norvegicus MRPL19 RGD RGD:1587381
Bos taurus MRPL19 VGNC VGNC:31622
Canis familiaris MRPL19 VGNC VGNC:43383
Felis catus MRPL19 VGNC VGNC:63597
Macaca mulatta MRPL19 VGNC VGNC:74743