SEPTIN7 - septin 7 Gene

中文名称：隔膜蛋白 7

种属: Homo sapiens

同用名: CDC3; CDC10; SEPT7; SEPT7A; NBLA02942

关于 SEPTIN7

功能概要

该基因编码的蛋白质与酿酒酵母的 CDC10 蛋白质高度相似。该蛋白质还与果蝇的 Diff 6 和小鼠的 H5 具有相似性。这些相似的蛋白质中的每一个，包括酵母 CDC10，都包含一个 GTP 结合基序。酵母 CDC10 蛋白是位于细胞质膜内的 10 nm 细丝的结构成分，对胞质分裂至关重要。这种人类蛋白质在神经胶质瘤形成和抑制神经胶质瘤细胞生长中起作用，并且它是着丝粒相关蛋白 E 与着丝粒结合所必需的。可变剪接导致多个转录本变体。已在 5、7、9、10、11、14、17 和 19 号染色体上鉴定出几个相关的假基因。[RefSeq 提供，2011 年 7 月]

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]