SV2B - synaptic vesicle glycoprotein 2B Gene

中文名称：突触小泡糖蛋白 2B

种属: Homo sapiens

同用名: SLC22B2; HsT19680

关于 SV2B

功能概要

该基因编码突触小泡蛋白 2 (SV2) 家族和主要促进蛋白超家族的成员。这种蛋白质和该家族的其他成员定位于突触小泡，并可能在调节小泡运输和胞吐作用中发挥作用。对小鼠的研究表明，编码的蛋白质可能充当神经元中肉毒杆菌神经毒素 E 的蛋白质受体，并且这种蛋白质可能对肾小球滤过屏障的完整性很重要。该基因在人类颞叶癫痫患者海马体突触缺失区域的表达减少。[RefSeq 提供，2016 年 9 月]

This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and Other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016]