2. Gene
  3. TMCC2 - transmembrane and coiled-coil domain family 2 Gene

TMCC2 - transmembrane and coiled-coil domain family 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：跨膜和卷曲螺旋结构域家族 2

种属: Homo sapiens

同用名: HUCEP11

基因 ID: 9911 | 基因类型: protein coding

关于 TMCC2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,227,946-205,273,343 (from NCBI)

This gene has 10 transcripts (splice variants), 222 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 19.2), brain (RPKM 7.1) and 4 other tissues.

功能概要

参与淀粉样前体蛋白的代谢过程。位于内质网。 [由基因组资源联盟提供，2022 年 4 月]

Involved in amyloid precursor protein metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

TMCC2 基因产物(7)

mRNA Protein Name
NM_001242925.2 NP_001229854.1 transmembrane and coiled-coil domains protein 2 isoform 2
NM_001297611.2 NP_001284540.1 transmembrane and coiled-coil domains protein 2 isoform 3
NM_001297613.2 NP_001284542.1 transmembrane and coiled-coil domains protein 2 isoform 4
NM_001331034.1 NP_001317963.1 transmembrane and coiled-coil domains protein 2 isoform 5
NM_001375651.1 NP_001362580.1 transmembrane and coiled-coil domains protein 2 isoform 2
NM_001375652.1 NP_001362581.1 transmembrane and coiled-coil domains protein 2 isoform 2
NM_014858.4 NP_055673.2 transmembrane and coiled-coil domains protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21593558 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid precursor protein metabolic process IDA
IDA: 通过直接分析推断
21593558 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
21593558 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMCC2 蛋白结构

Tmemb_cc2

Tmemb_cc2: Predicted transmembrane and coiled-coil 2 protein (284 - 697)

  • 0
  • 200
  • 400
  • 600
  • 709 a.a.
蛋白主名 其他名称

transmembrane and coiled-coil domains protein 2

cerebral protein 11

TMCC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TMCC2 O75069 APOE Homo sapiens P02649
Anti Tag CoIP
21593558
种属内
TMCC2 O75069 APOE Homo sapiens P02649
Y2H
21593558
种属内
TMCC2 O75069 APOE Homo sapiens P02649
Fluorescence Spectr
21593558
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Noonan Syndrome 10

NS10

Noonan Syndrome, Type 10
Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14630 TMCC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TMCC2 VGNC VGNC:66240
Mus musculus TMCC2 MGD MGI:1916125
Canis familiaris TMCC2 VGNC VGNC:47429
Bos taurus TMCC2 VGNC VGNC:35926
Macaca mulatta TMCC2 VGNC VGNC:79423
Rattus norvegicus TMCC2 RGD RGD:1311960
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