2. Gene
  3. OXSR1 - oxidative stress responsive kinase 1 Gene

OXSR1 - oxidative stress responsive kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：氧化应激反应激酶 1

种属: Homo sapiens

同用名: OSR1

基因 ID: 9943 | 基因类型: protein coding

关于 OXSR1

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,164,063-38,255,484 (from NCBI)

This gene has 6 transcripts (splice variants), 98 orthologues and 35 paralogues. Ubiquitous expression in esophagus (RPKM 13.6), bone marrow (RPKM 11.2) and 25 other tissues.

功能概要

该基因的产物属于 Ser/Thr 蛋白激酶蛋白家族。它调节下游激酶以响应环境压力，并可能在调节肌动蛋白细胞骨架中发挥作用。[RefSeq 提供，2008 年 7 月]

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin Cytoskeleton. [provided by RefSeq, Jul 2008]

OXSR1 基因产物(1)

mRNA Protein Name
NM_005109.3 NP_005100.1 serine/threonine-protein kinase OSR1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
14707132 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16832045 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
14707132 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16669787 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
16669787 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
14707132 GOA
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
16669787 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell volume homeostasis IDA
IDA: 通过直接分析推断
36318922 GOA
involved in cellular hyperosmotic response IDA
IDA: 通过直接分析推断
36318922 GOA
involved in cellular response to chemokine IMP
IMP: 通过突变表型推断
27400149 GOA
involved in chemokine (C-X-C motif) ligand 12 signaling pathway IMP
IMP: 通过突变表型推断
27400149 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
14707132 GOA
involved in osmosensory signaling pathway IMP
IMP: 通过突变表型推断
16669787 GOA
involved in peptidyl-threonine phosphorylation IDA
IDA: 通过直接分析推断
24393035 GOA
involved in peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
16669787 GOA
involved in positive regulation of T cell chemotaxis IMP
IMP: 通过突变表型推断
27400149 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
22052202 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
14707132 GOA
involved in renal sodium ion absorption IDA
IDA: 通过直接分析推断
18270262 GOA
involved in signal transduction IMP
IMP: 通过突变表型推断
16669787 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytoplasm IDA
IDA: 通过直接分析推断
22989884 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OXSR1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (17 - 291)

OSR1_C

OSR1_C: Oxidative-stress-responsive kinase 1 C-terminal domain (434 - 464)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 527 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase OSR1

oxidative stress responsive 1

重组 OXSR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77119 OXSR1 Protein, Human (sf9, GST) O95747 (M1-S527) ≥95%

关联疾病

疾病名称 别名
Hypomagnesemia 4, Renal

Renal Hypomagnesemia 4

HOMG4

Hypomagnesemia, Renal, Normocalciuric

Hypomagnesemia 4

Renal Hypomagnesemia Normocalciuric

Hypomagnesemia, Type 4, Renal
Arthrogryposis, Distal, Type 3

Gordon Syndrome

DA3

Distal Arthrogryposis Type 3

Arthrogryposis Multiplex Congenita, Distal, Type Iia

Camptodactyly, Cleft Palate, And Clubfoot

Camptodactyly-Cleft Palate-Clubfoot Syndrome

Distal Arthrogryposis Multiplex Congenita Type Iia

Arthrogryposis Distal Type 3

Distal Arthrogryposis Type Iia

Arthrogryposis, Distal, 3

Pseudohypoaldosteronism, Type Ii
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09892 OXSR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus OXSR1 RGD RGD:1310466
Felis catus OXSR1 VGNC VGNC:97546
Macaca mulatta OXSR1 VGNC VGNC:81491
Mus musculus OXSR1 MGD MGI:1917378
Canis familiaris OXSR1 VGNC VGNC:44205
Bos taurus OXSR1 VGNC VGNC:32514
Others OXSR1 NCBI
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