2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. GR-46611

GR-46611 是一种 5-HT1D 受体激动剂。GR-46611 可用于膀胱多动症、白血病的研究。

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GR-46611 Chemical Structure

GR-46611 Chemical Structure

CAS No. : 185259-85-2

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规格 价格 是否有货 数量
1 mg ￥457
In-stock
5 mg ￥1050
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10 mg ￥1700
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25 mg ￥3400
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50 mg ￥5400
In-stock
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Customer Review

GR-46611 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GR-46611 is a 5-HT1D receptor agonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia[1][3].

IC50 & Target[1]

5-HT1D Receptor

 

体外研究
(In Vitro)

GR-46611 (1 μM, 48 h) induces CEM cell proliferation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GR-46611 相关抗体:

Cell Proliferation Assay[2]

Cell Line: CEM cells (human T lymphoblastic leukemia cell line)
Concentration: 1 μM
Incubation Time: 48 h
Result: Induced a significant increase in cell proliferation by 37.0%.
体内研究
(In Vivo)

GR-46611 (1 mg/kg, i.p. ) significantly improves survival of Dravet syndrome (DS) mice[1].
GR-46611 (0.03-300 μg/kg, i.v.) increases threshold volume, bladder capacity, and residual volume in chronic spinal cord injury (SCI) cats[3].
GR46611 (3-30 mg/kg, s.c.) causes a dose-related decrease in rectal temperature in the adult guinea-pig[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dravet syndrome (DS) mice[1]
Dosage: 0.01, 0.1 and 1 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Improved survival relative to vehicle treated controls with 89% surviving rate.
分子量

377.48

Formula

C23H27N3O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (264.91 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6491 mL 13.2457 mL 26.4915 mL
5 mM 0.5298 mL 2.6491 mL 5.2983 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

GR-46611 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6491 mL 13.2457 mL 26.4915 mL 66.2287 mL
5 mM 0.5298 mL 2.6491 mL 5.2983 mL 13.2457 mL
10 mM 0.2649 mL 1.3246 mL 2.6491 mL 6.6229 mL
15 mM 0.1766 mL 0.8830 mL 1.7661 mL 4.4152 mL
20 mM 0.1325 mL 0.6623 mL 1.3246 mL 3.3114 mL
25 mM 0.1060 mL 0.5298 mL 1.0597 mL 2.6491 mL
30 mM 0.0883 mL 0.4415 mL 0.8830 mL 2.2076 mL
40 mM 0.0662 mL 0.3311 mL 0.6623 mL 1.6557 mL
50 mM 0.0530 mL 0.2649 mL 0.5298 mL 1.3246 mL
60 mM 0.0442 mL 0.2208 mL 0.4415 mL 1.1038 mL
80 mM 0.0331 mL 0.1656 mL 0.3311 mL 0.8279 mL
100 mM 0.0265 mL 0.1325 mL 0.2649 mL 0.6623 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GR-46611185259-85-2GR46611GR 466115-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorDravet syndromeDS miceseizureepilepsyrapheserotoninCEMleukemiaInhibitorinhibitorinhibit

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产品名称：
GR-46611
目录号：
HY-101248
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