2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. GrTx1

GrTx1 是一种肽毒素，最初从Grammostola rosea 蜘蛛的毒液中分离出来。GrTx1 能阻断钠离子通道(sodium channel)，对 Nav1.1，Nav1.2，Nav1.3，Nav1.4，Nav1.6 和 Nav1.7 的 IC50 值分别为 0.63 µM, 0.23 µM, 0.77 µM, 1.29 µM, 0.63 µM and 0.37 µM。GrTx1 可用于神经疾病研究。

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Custom Peptide Synthesis

GrTx1 Chemical Structure

GrTx1 Chemical Structure

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Customer Review

GrTx1 相关抗体

Top Publications Citing Use of Products

查看 Sodium Channel 亚型特异性产品:

查看所有亚型
Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel， with IC50s of 0.63 µM, 0.23 µM, 0.77 µM, 1.29 µM, 0.63 µM and 0.37 µM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively[2].GrTx1 can be used for neurological disease research[1].

体外研究
(In Vitro)

GrTx1 (0-100 μΜ, 3 分钟) 能阻断神经母细胞瘤 F-11 细胞的 Na+ 电流，IC50 值为 2.8 μM[1]。 GrTx1 (0-100 μΜ, 3 分钟) 能阻断神经母细胞瘤 F-11 细胞约 85% 的 Na+ 电流，对常见的 K+ 通道如 Kv1.1 和 1.4 没有影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GrTx1 相关抗体:
分子量

3697.43

Formula

C159H243N45O41S8
Sequence

Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Lys-Arg-Lys-Cys-Cys-Glu-Asp-Met-Val-Cys-Gln-Leu-Trp-Cys-Lys-Lys-Arg-Leu (Disulfide bonds: Cys2-Cys16, Cys9-Cys21, Cys15-Cys25)
Sequence Shortening

YCQKWMWTCDSKRKCCEDMVCQLWCKKRL (Disulfide bonds: Cys2-Cys16, Cys9-Cys21, Cys15-Cys25)
初始来源

Grammostola rosea
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GrTx1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GrTx1GrTx 1GrTx-1Sodium ChannelNa channelsNa+ channelssodium channelneuroblastoma F-11 cellsGrammostola roseapeptide toxinInhibitorinhibitorinhibit

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