2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. hAChE/Aβ1-42-IN-1

hAChE/Aβ1-42-IN-1 (Compound 16) 是一种有效的 hAChE 和 Aβ1-42 聚集抑制剂。hAChE/Aβ1-42-IN-1 对 hepG2 细胞系显示出可接受的相对安全性，并具有良好的 BBB 渗透性和较宽的安全范围。hAChE/Aβ1-42-IN-1具有研究阿尔茨海默病 (AD) 的潜力。

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hAChE/Aβ1-42-IN-1 Chemical Structure

hAChE/Aβ1-42-IN-1 Chemical Structure

CAS No. : 2761149-17-9

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hAChE/Aβ1-42-IN-1 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hAChE/Aβ1-42-IN-1 (Compound 16) is a potent inhibitor of hAChE and Aβ1-42 aggregation. hAChE/Aβ1-42-IN-1 shows acceptable relative safety upon hepG2 cell line and excellent BBB penetration with wide safety margin. hAChE/Aβ1-42-IN-1 has the potential for the research of Alzheimer disease (AD)[1].

IC50 & Target

AChE

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
25 μM
Compound: 16
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 35101650]
分子量

364.44

Formula

C20H24N6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hAChE/Aβ1-42-IN-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hAChE/Aβ1-42-IN-12761149-17-9Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetahAChEAβ1-42 aggregationsafetyBBB penetrationAlzheimer diseaseInhibitorinhibitorinhibit

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