2. Immunology/Inflammation Anti-infection
  3. COX Parasite
  4. Hirsutanonol

Hirsutanonol  (Synonyms: (5S)-Hirsutanonol)

目录号: HY-N4044
产品使用指南

摩尔计算器

Hirsutanonol ((5S)-Hirsutanonol) 是一种可从 Alnus hirsute var. sibirica 的树皮中分离得到的二芳基庚烷。Hirsutanonol 抑制环氧合酶-2 (COX-2) 的表达。Hirsutanonol 具有抗丝虫作用，对微丝蚴的 IC50 值为 44.11 μg/mL。

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Hirsutanonol Chemical Structure

Hirsutanonol Chemical Structure

CAS No. : 41137-86-4

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Hirsutanonol 相关抗体

Top Publications Citing Use of Products

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COX COX-1 COX-2 COX-3

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hirsutanonol ((5S)-Hirsutanonol) is a diarylheptanoid that can be isolated from the bark of Alnus hirsute var. sibirica. Hirsutanonol inhibits cyclooxygenase-2 (COX-2) expression. Hirsutanonol has anti-filarial with an IC50 value of 44.11 μg/mL for microfilariae[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
17.8 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess method
[PMID: 33422907]
RAW264.7 IC50
19.3 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis
[PMID: 33422907]
RAW264.7 IC50
21.3 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
[PMID: 33422907]
RAW264.7 IC50
23.7 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 1 hr followed by LPS stimulation and measured after 18 hrs by immunoassay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production preincubated for 1 hr followed by LPS stimulation and measured after 18 hrs by immunoassay
[PMID: 33422907]
RAW264.7 IC50
25.7 μg/mL
Compound: 2
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis
[PMID: 33422907]
RAW264.7 IC50
3.8 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 20 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 20 hrs by Griess assay
[PMID: 33422907]
RAW264.7 IC50
30 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 0.5 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 0.5 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis
[PMID: 33422907]
RAW264.7 IC50
44.3 μg/mL
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 24 hrs by Griess assay
[PMID: 33422907]
RAW264.7 IC50
9.9 μM
Compound: 2
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kappaB activation incubated for 24 hrs by SEAP microplate reader analysis
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kappaB activation incubated for 24 hrs by SEAP microplate reader analysis
[PMID: 33422907]
分子量

346.37

Formula

C19H22O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hirsutanonol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hirsutanonol41137-86-4(5S)-HirsutanonolCOXParasiteCyclooxygenasediarylheptanoidbarkfilarialmicrofilariaenatural compoundInhibitorinhibitorinhibit

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