2. Anti-infection
  3. HIV
  4. HIV-1 inhibitor-6

HIV-1 inhibitor-6 

目录号: HY-134851 纯度: 98.91%
COA 产品使用指南

摩尔计算器

HIV-1 inhibitor-6 (compound 9) 是一种基于二杂芳基酰胺的化合物，是一种有效的 HIV-1 pre-mRNA 选择性剪接抑制剂。HIV-1 inhibitor-6 可以阻断 HIV 复制。HIV-1 inhibitor-6 对野生型 HIV-1IIIB (亚型 B，X4-tropic) 和 HIV-1 97USSN54 (亚型 A，R5-tropic) 具有活性，EC50 值分别为 0.6 μM 和 0.9 μM。HIV-1 inhibitor-6 抑制对靶向 HIV 逆转录酶、蛋白酶、整合酶和辅助受体 CCR5 的活性分子耐药的 HIV 菌株，EC50 范围为 0.9 至 1.5 μM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

HIV-1 inhibitor-6 Chemical Structure

HIV-1 inhibitor-6 Chemical Structure

CAS No. : 1821309-39-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1590
In-stock
5 mg ￥3500
In-stock
10 mg ￥6000
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

HIV-1 inhibitor-6 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 HIV 亚型特异性产品:

查看所有亚型
HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC50s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC50s ranging from 0.9 to 1.5 μM[1].

IC50 & Target[1]

X4 HIV-1 (IIIB)

0.6 μM (EC50)

R5 HIV-1

0.9 μM (EC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM CC50
> 100 μM
Compound: 9; 1C8
Cytotoxicity against GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 assessed as cell viability at after 24 hrs by Guava viacount assay
Cytotoxicity against GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 assessed as cell viability at after 24 hrs by Guava viacount assay
[PMID: 26878150]
CCRF-CEM EC50
0.6 μM
Compound: 9; 1C8
Antiviral activity against subtype B X4 tropic HIV1 3B infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
Antiviral activity against subtype B X4 tropic HIV1 3B infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
[PMID: 26878150]
CCRF-CEM EC50
0.9 μM
Compound: 9; 1C8
Antiviral activity against subtype A R5 tropic HIV1 97USSN54 infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
Antiviral activity against subtype A R5 tropic HIV1 97USSN54 infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
[PMID: 26878150]
CCRF-CEM EC50
0.9 μM
Compound: 9; 1C8
Antiviral activity against maraviroc-resistant HIV1 BAL R5 harboring envelop V3 A19T/L20F/T22A/E25D/126V mutant infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
Antiviral activity against maraviroc-resistant HIV1 BAL R5 harboring envelop V3 A19T/L20F/T22A/E25D/126V mutant infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
[PMID: 26878150]
CCRF-CEM EC50
1.3 μM
Compound: 9; 1C8
Antiviral activity against NNRTI-resistance HIV1 E00443 harboring reverse transcriptase D67N/K70R/Y115F/Q151M/M184V/K219Q mutant infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
Antiviral activity against NNRTI-resistance HIV1 E00443 harboring reverse transcriptase D67N/K70R/Y115F/Q151M/M184V/K219Q mutant infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
[PMID: 26878150]
CCRF-CEM EC50
1.4 μM
Compound: 9; 1C8
Antiviral activity against PI-resistant HIV1 isolate 2948 harboring protease G48V/L90M mutant infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
Antiviral activity against PI-resistant HIV1 isolate 2948 harboring protease G48V/L90M mutant infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
[PMID: 26878150]
CCRF-CEM EC50
1.5 μM
Compound: 9; 1C8
Antiviral activity against INI-resistant HIV1 isolate 11845 harboring integrase G140S/Q148H mutant infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
Antiviral activity against INI-resistant HIV1 isolate 11845 harboring integrase G140S/Q148H mutant infected in GFP-positive human CEM cells expressing CD4+,CXCR4 and CCR5 after 3 days
[PMID: 26878150]
分子量

330.32

Formula

C14H10N4O4S
CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 3.33 mg/mL (10.08 mM; 超声助溶 (<80°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0274 mL 15.1368 mL 30.2737 mL
5 mM 0.6055 mL 3.0274 mL 6.0547 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

HIV-1 inhibitor-6 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0274 mL 15.1368 mL 30.2737 mL 75.6842 mL
5 mM 0.6055 mL 3.0274 mL 6.0547 mL 15.1368 mL
10 mM 0.3027 mL 1.5137 mL 3.0274 mL 7.5684 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-61821309-39-0HIVHuman immunodeficiency virusDiheteroarylamideHIV-1pre-mRNA alternative splicingreplicationHIV-1IIIBX4-tropic97USSN54R5-tropicreverse transcriptaseproteaseintegrasecoreceptor CCR5Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
HIV-1 inhibitor-6
目录号：
HY-134851
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z