2. Apoptosis
  3. Apoptosis
  4. HS-1793

HS-1793 是一种 Resveratrol 类似物，在多种癌细胞中具有抗肿瘤活性。HS-1793 诱导细胞凋亡 (apoptosis)。

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HS-1793 Chemical Structure

HS-1793 Chemical Structure

CAS No. : 927885-00-5

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规格 价格 是否有货 数量
1 mg ￥360
In-stock
5 mg ￥900
In-stock
10 mg ￥1500
In-stock
25 mg ￥2475
In-stock
50 mg ￥3465
In-stock
100 mg ￥4851
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Customer Review

HS-1793 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HS-1793 is a Resveratrol (HY-16561) analogue with antitumor activities in a variety of cancer cell lines[1]. HS-1793 induces cell apoptosis[2].

体外研究
(In Vitro)

HS-1793 (0-100 µM; 24 h) suppresses proliferation of MCF-7, MDA-MB-231 and HCT116 cells[1][2].
HS-1793 (0-50 µM; 4 h) inhibits hypoxia-induced HIF-1α protein in MCF-7 and MDA-MB-231 cells unrelated to cell death, downregulates hypoxia-induced VEGF expression, and suppresses hypoxia-induced mRNA expression of VEGF at the transcriptional level[1].
HS-1793 (0-100 µM; 24 h) induces apoptosis, promotes G2/M cell cycle arrest, and inhibits Akt and ERK phosphorylation in HCT116 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HS-1793 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MCF-7, MDA-MB-231 and MCF-10A
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Showed antiproliferation activity with IC50 values of 26.3±3.2, 48.2±4.2 and >100 μM against MCF-7, MDA-MB-231 and MCF-10A, respectively.

Western Blot Analysis[1]

Cell Line: MCF-7, MDA-MB-231
Concentration: 12.5, 25 and 50 μM
Incubation Time: 4 h
Result: Downregulated HIF-1α expression in a concentration-dependent manner in both cell lines.

RT-PCR[1]

Cell Line: MCF-7, MDA-MB-231
Concentration: 12.5, 25 and 50 μM
Incubation Time: 4 h
Result: Downregulated the expression of VEGF mRNA, with the more marked results observed in MDA-MB-231 cells.

Cell Proliferation Assay[2]

Cell Line: HCT116
Concentration: 12.5, 25, 50 and 100 µM
Incubation Time: 1, 2 and 4 days
Result: Significantly reduced the cell viability concentration- and time-dependently. Significantly suppressed proliferation of colon cancer cell line HCT116.

Apoptosis Analysis[2]

Cell Line: HCT116
Concentration: 12.5, 25, 50 and 100 µM
Incubation Time: 24 h
Result: Induced cell apoptosis in a dose-dependent manner. Caused chromatin condensation and fragmentation.

Western Blot Analysis[2]

Cell Line: HCT116
Concentration: 12.5, 25, 50 and 100 µM
Incubation Time: 24 h
Result: Effectively induced the reduction of pro-caspase-8 and pro-caspase-3 at 100 µM. Activated caspase-8 and caspase-3. Caused the PARP cleavage. Slightly downregulated the level of antiapoptotic protein Bcl-2 at 100 µM. Promoted an increase in the release of cytochrome c from the mitochondria into the cytosol. Decreased the expression of G2/M cell cycle regulatory protein cyclin B1, Cdc2 and Cdc25C. Decreased the level of CDK4 and CDK6. Decreased Akt phosphorylation and reduced total Akt at high-concentration. Decreased the phosphorylation of ERK1/2 without affecting the protein level.

Cell Cycle Analysis[2]

Cell Line: HCT116
Concentration: 12.5, 25 and 50 µM
Incubation Time: 24 h
Result: Induced the accumulation of cells in the G2/M phase in a concentration-dependent manner.
体内研究
(In Vivo)

HS-1793 (5 and 10 mg/kg; i.p.; twice a week, 4 weeks) significantly inhibits MDA-MB-231 xenograft tumor growth and in a dose-dependent manner and relatively hampers angiogenesis with non-toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old female BALB/c nude mice injected with MDA-MB-231 cells[1]
Dosage: 5 mg/kg and 10 mg/kg (dissolved in PBS containing 0.1% v/v dimethyl sulfoxide (DMSO))
Administration: Intraperitoneal injection, twice a week, 4 weeks
Result: Significantly inhibited MDA-MB-231 xenograft tumor growth in a dose-dependent manner with non-toxicity. Significantly lowered Ki-67 (a proliferation marker) and CD31 expression. Successfully suppressed the expression of HIF-1α and VEGF in tumor tissues.
分子量

252.26

Formula

C16H12O3
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (495.52 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9642 mL 19.8208 mL 39.6416 mL
5 mM 0.7928 mL 3.9642 mL 7.9283 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

HS-1793 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9642 mL 19.8208 mL 39.6416 mL 99.1041 mL
5 mM 0.7928 mL 3.9642 mL 7.9283 mL 19.8208 mL
10 mM 0.3964 mL 1.9821 mL 3.9642 mL 9.9104 mL
15 mM 0.2643 mL 1.3214 mL 2.6428 mL 6.6069 mL
20 mM 0.1982 mL 0.9910 mL 1.9821 mL 4.9552 mL
25 mM 0.1586 mL 0.7928 mL 1.5857 mL 3.9642 mL
30 mM 0.1321 mL 0.6607 mL 1.3214 mL 3.3035 mL
40 mM 0.0991 mL 0.4955 mL 0.9910 mL 2.4776 mL
50 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
60 mM 0.0661 mL 0.3303 mL 0.6607 mL 1.6517 mL
80 mM 0.0496 mL 0.2478 mL 0.4955 mL 1.2388 mL
100 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9910 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HS-1793927885-00-5HS1793HS 1793ApoptosisresveratrolMCF-7MDA-MB-231HIF-1αcolon cancerbreast cancerHCT116VEGFAktERKInhibitorinhibitorinhibit

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目录号：
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