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  3. HIV Bacterial
  4. Ilimaquinone

Ilimaquinone 是一种海洋海绵状代谢产物，通过 GADD153 介导的信号通路发挥抗肿瘤活性。Ilimaquinone 可以诱导高尔基体的囊泡化。Ilimaquinone 具有抗病毒，抗菌和抗炎活性。

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Ilimaquinone Chemical Structure

Ilimaquinone Chemical Structure

CAS No. : 71678-03-0

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规格 价格 是否有货 数量
100 μg ￥3200
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Ilimaquinone 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Ilimaquinone can induce vesiculation of the Golgi apparatus[1]. Ilimaquinone exerts anti-HIV, anti-microbial, anti-inflammatory, and effects[2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.4 μg/mL
Compound: 4
Cytotoxicity against human A549 cells after 6 days by MTT assay
Cytotoxicity against human A549 cells after 6 days by MTT assay
[PMID: 9051909]
A549 IC50
5.9 μM
Compound: 14
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
[PMID: 28558970]
BV-2 IC50
10.4 μM
Compound: 7
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-stimulated nitric oxide production by Griess assay
[PMID: 28262525]
CHO-K1 GI50
2 μM
Compound: 1
Cytotoxicity against human CHOK1 cells after 48 hrs by SRB assay
Cytotoxicity against human CHOK1 cells after 48 hrs by SRB assay
[PMID: 21155589]
HeLa IC50
> 10 μM
Compound: 1
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
[PMID: 32040314]
HeLa IC50
7.6 μM
Compound: 14
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by WST8 assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 72 hrs by WST8 assay
[PMID: 28558970]
HT-29 GI50
5.4 μM
Compound: 1
Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay
[PMID: 21155589]
MCF7 IC50
> 10 μM
Compound: 1
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by sulforhodamine B assay
[PMID: 32040314]
MCF7 GI50
3.9 μM
Compound: 1
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
[PMID: 21155589]
MCF7 IC50
8.3 μM
Compound: 14
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
[PMID: 28558970]
NCI-H460 GI50
1.8 μM
Compound: 1
Cytotoxicity against human H460 cells after 48 hrs by SRB assay
Cytotoxicity against human H460 cells after 48 hrs by SRB assay
[PMID: 21155589]
P388 IC50
0.2 μg/mL
Compound: 4
Cytotoxicity against mouse P388 cells after 3 days by MTT assay
Cytotoxicity against mouse P388 cells after 3 days by MTT assay
[PMID: 9051909]
PC-3 IC50
> 10 μM
Compound: 1
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability by MTT assay
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability by MTT assay
[PMID: 32040314]
SF-268 GI50
2.7 μM
Compound: 1
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
[PMID: 21155589]
WI-38 IC50
9.7 μM
Compound: 14
Cytotoxicity against human WI38 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
Cytotoxicity against human WI38 cells assessed as decrease in cell viability after 72 hrs by WST8 assay
[PMID: 28558970]
体外研究
(In Vitro)

Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM ; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI50s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ilimaquinone 相关抗体:

Cell Viability Assay[1]

Cell Line: Prostate cancer PC-3 cells
Concentration: 0.3, 1, 3, 10, and 30 μM
Incubation Time: 48 hours
Result: Inhibited the proliferation of PC-3 cells in a concentration-dependent manner.
体内研究
(In Vivo)

Ilimaquinone exhibits terminal elimination half-lives (T1/2=1.2±0.3 h) due to high plasma clearance (2.95±0.53 L/h/kg) following oral administration (10 mg/kg) in male Sprague-Dawley rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

358.47

Formula

C22H30O4
CAS 号
性状

固体

颜色

Light yellow to brown

结构分类
初始来源

marine sponge Halichondria sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (69.74 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7896 mL 13.9482 mL 27.8963 mL
5 mM 0.5579 mL 2.7896 mL 5.5793 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (175 KB)

产品使用指南 (1538 KB)
参考文献

Ilimaquinone 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7896 mL 13.9482 mL 27.8963 mL 69.7408 mL
5 mM 0.5579 mL 2.7896 mL 5.5793 mL 13.9482 mL
10 mM 0.2790 mL 1.3948 mL 2.7896 mL 6.9741 mL
15 mM 0.1860 mL 0.9299 mL 1.8598 mL 4.6494 mL
20 mM 0.1395 mL 0.6974 mL 1.3948 mL 3.4870 mL
25 mM 0.1116 mL 0.5579 mL 1.1159 mL 2.7896 mL
30 mM 0.0930 mL 0.4649 mL 0.9299 mL 2.3247 mL
40 mM 0.0697 mL 0.3487 mL 0.6974 mL 1.7435 mL
50 mM 0.0558 mL 0.2790 mL 0.5579 mL 1.3948 mL
60 mM 0.0465 mL 0.2325 mL 0.4649 mL 1.1623 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ilimaquinone71678-03-0HIVBacterialHuman immunodeficiency virusmarinespongemetaboliteanticancerGADD153Golgiapparatusanti-HIVanti-microbialanti-inflammatoryInhibitorinhibitorinhibit

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目录号：
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