2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Adrenergic Receptor iGluR
  4. Isoxsuprine

Isoxsuprine  (Synonyms: 异克舒令；异舒普林)

目录号: HY-B1270A
产品使用指南

摩尔计算器

Isoxsuprine 是 β 肾上腺素受体激动剂，对于子宫肌层和胎盘的 β 肾上腺素受体的 Ki 值分别为 13.65 μM 和 3.48 μM。Isoxsuprine hydrochloride 也是一种 NMDA 受体拮抗剂。

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Isoxsuprine Chemical Structure

Isoxsuprine Chemical Structure

CAS No. : 395-28-8

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Isoxsuprine 的其他形式现货产品:

Other Forms of Isoxsuprine:

Isoxsuprine 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Isoxsuprine is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.

IC50 & Target

Ki: 13.65 μΜ (myometrial beta-adrenergic receptor), 3.48 μΜ (placcntal beta-adrenergic receptor)[1]
NMDA receptor[3]
体外研究
(In Vitro)

Results show that Isoxsuprine inhibits CCID formation dose dependently (5 to 60 μM) and also inhibits 12(S)-HETE synthesis. Furthermore, Isoxsuprine is the only drug inhibiting the induction of all three mobility markers (MLC2, MYPT and paxillin)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Isoxsuprine 相关抗体:
体内研究
(In Vivo)

Total infarct volume in vehicle-treated animals is 279±25 mm3 compare to 137±18 mm3 in Isoxsuprine -treated animals[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

301.38

Formula

C18H23NO3
CAS 号
中文名称

异克舒令；异舒普林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Cell Assay
[2]

MCF-7ALOX12 cells are seeded in 3.5-cm dishes and grown in 2.5 mL complete MEM medium without selection pressure. The next day, the medium is changed to serum-free medium and cells are kept at 37 °C for 24 h. Then, cells are treated with 10 μM arachidonic acid and simultaneously with different concentrations of Isoxsuprine for 4 h when the supernatants are aspirated, centrifuged at 2000, r.p.m. at 4 °C for 5 min, collected in cryo-tubes, flash frozen and stored at -80 °C until analysis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[3]

Male spontaneously hypertensive rats (SHR) weighing 290 to 300 g are used in this study. At reperfusion, animals receive 0.5 mL of vehicle (0.6% DMSO in normal saline) or 1 mg/kg Isoxsuprine by intravenous (IV) injection through the lateral tail vein. All animals receive 3 mL of subcutaneous saline after surgery to prevent dehydration. After 24 hours reperfusion, animals are sacrificed, brains are sectioned into 4 mm-thick quadrants, and infarcted tissue is identified by 2,3,5-triphenyltetrazolium chloride (TTC) staining. Edema-corrected infarct volume is calculated by subtracting the area of non-infarcted tissue in the ipsilateral hemisphere from the total volume of the contralateral hemisphere. Infarct volume is quantified using Image J software[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Isoxsuprine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

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Keywords:

Isoxsuprine395-28-8异克舒令异舒普林Adrenergic ReceptoriGluRBeta ReceptorIonotropic glutamate receptorsInhibitorinhibitorinhibit

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