2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Izalontamab

Izalontamab  (Synonyms: SI-B001)

目录号: HY-P99676 纯度: 99.03%
COA

摩尔计算器

Izalontamab (SI-B001) 是一种双特异性抗 EGFR/HER3 单克隆抗体，对 EGFR/HER3 异源二聚体具有高选择性。Izalontamab 可用于癌症研究。

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CAS No. : 2559704-24-2

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规格 价格 是否有货 数量
1 mg ￥6500
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Izalontamab 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Chimeric; Humanized
体内研究
(In Vivo)

Izalontamab (5-46 mg/kg；静脉注射，每 7 天 1 次，共 4 次) 对不同类型肿瘤显示不同的抗肿瘤疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/SCID mouse with SW48, FaDu and KYSE-150 xenografts[1]
Dosage: 10, 25 and 46 mg/kg (SW48); 5, 10 and 25 mg/kg (FaDu and KYSE-150)
Administration: Intravenous injection; 10, 25 and 46 mg/kg (SW48); 5, 10 and 25 mg/kg (FaDu and KYSE-150); every 7 days once, 4 doses in total
Result: Dose-dependently inhibited the growth of FaDu and KYSE-150 tumors at the dose of 10 mg/kg. Inhibited 63.6% SW48 tumor growth at the dose of 46 mg/kg.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG1-kappa-[scFv-heavy-lambda]2
Biological Activity
  • Immobilized Human HER3/ERBB3 Protein (ECD, His Tag) can bind Izalontamab. The EC50 for this effect is 1.98 ng/mL.
  • Immobilized Human EGFR Protein (ECD, His Tag) can bind Izalontamab. The EC50 for this effect is 2.53 ng/mL.
纯度 & 产品资料
参考文献

Izalontamab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Izalontamab2559704-24-2SI-B001EGFREpidermal growth factor receptorErbB-1HER1bispecificheterodimeranti-tumorSW48FaDuKYSE-150Inhibitorinhibitorinhibit

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