2. Epigenetics
  3. Histone Methyltransferase
  4. JNJ-7925476

JNJ-7925476是一种三重再摄取抑制剂，具有选择性和强效抑制血清素转运体（SERT）、去甲肾上腺素转运体（NET）和多巴胺转运体（DAT）的活性。JNJ-7925476可迅速被吸收入血，且在大脑中的浓度比血浆高7倍。JNJ-7925476在大鼠大脑中对SERT、NET和DAT的占据ED(50)值分别为0.18、0.09和2.4 mg/kg。JNJ-7925476以剂量依赖的方式迅速诱导大鼠大脑皮层中细胞外血清素、多巴胺和去甲肾上腺素水平的显著增加。JNJ-7925476在小鼠悬尾实验中表现出强效的抗抑郁样活性。这些结果表明JNJ-7925476在抑郁症的生化和行为模型中具有体内疗效。

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JNJ-7925476 Chemical Structure

JNJ-7925476 Chemical Structure

CAS No. : 129540-12-1

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JNJ-7925476 相关抗体

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查看 Histone Methyltransferase 亚型特异性产品:

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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生物活性

JNJ-7925476 is a triple reuptake inhibitor that selectively and potently inhibits the activity of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). JNJ-7925476 is rapidly absorbed into the blood and its concentration in the brain is 7-fold higher than that in plasma. The occupancy ED(50) values of JNJ-7925476 for SERT, NET, and DAT in the rat brain are 0.18, 0.09, and 2.4 mg/kg, respectively. JNJ-7925476 rapidly induces a significant increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex in a dose-dependent manner. JNJ-7925476 exhibits potent antidepressant-like activity in the mouse tail suspension test. These results suggest that JNJ-7925476 has in vivo efficacy in biochemical and behavioral models of depression[1].

分子量

273.37

Formula

C20H19N
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ-7925476 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-7925476129540-12-1JNJ7925476JNJ 7925476Histone MethyltransferaseInhibitorinhibitorinhibit

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