2. Anti-infection
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  4. Koshidacin B

Koshidacin B 是抗疟原虫环四肽，对热带疟原虫 (P. falciparum) FCR3 和 K1 系抗疟原虫活性的 IC50 值分别为 0.89 和 0.83 μM。Koshidacin B 在体内抑制疟原虫，可用于疟原虫感染的研究。

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Koshidacin B Chemical Structure

Koshidacin B Chemical Structure

CAS No. : 2925302-01-6

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Koshidacin B 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection[1].

IC50 & Target

IC50: 0.89 μM (P. falciparum FCR3 strain), 0.83 μM (P. falciparum K1 strain), 14.7 μM (human MRC-5 cells)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MRC5 CC50
14.7 μM
Compound: 2
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 36282784]
体外研究
(In Vitro)

Koshidacin B (72 h) shows antiplasmodial activity against chloroquine-sensitive P. falciparum FCR3 strain and chloroquine-resistant P. falciparum K1 strain with IC50 values of 0.89 and 0.83 μM, respectively[1].
Koshidacin B (7 d) shows cytotoxicity against human MRC-5 cells with an IC50 value of 14.7 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Koshidacin B 相关抗体:
体内研究
(In Vivo)

Koshidacin B (30 mg/kg; i.p.; once daily for 4 d) shows vivo antiplasmodial effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. berghei N strain-infected ICR (CD1) mice[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 30 mg/kg; once daily; for 4 days
Result: Suppressed 41% of malaria parasites.
分子量

544.64

Formula

C28H40N4O7
CAS 号
结构分类
初始来源

Pochonia boninensis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Koshidacin B 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Koshidacin B2925302-01-6Parasitecyclic tetrapeptideFCR3K1antiplasmodialMRC-5CD1malaria parasiteInhibitorinhibitorinhibit

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目录号：
HY-N10624
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