2. Academic Validation
  3. Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0564

Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0564

  • J Nat Prod. 2022 Oct 25. doi: 10.1021/acs.jnatprod.2c00719.
Yoshihiro Watanabe 1 2,  Kodai Hachiya 3,  Akari Ikeda 1 2,  Kenichi Nonaka 1 2,  Mayuka Higo 1 2,  Reiko Muramatsu 1,  Chikako Noguchi 1,  Masako Honsho 1,  Yukihiro Asami 1 2,  Yuki Inahashi 1 2,  Tomoyasu Hirose 1 2,  Hidehito Matsui 1 2,  Toshiaki Sunazuka 1 2,  Hideaki Hanaki 1 2,  Takahiro Ishii 4,  Toshiaki Teruya 5,  Rei Hokari 1 2,  Aki Ishiyama 1 2,  Masato Iwatsuki 1 2
Affiliations

Affiliations

  • 1 O̅mura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
  • 2 Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
  • 3 Graduate School of Science, Kitasato University, 1-15-1, Kitazato, Minami-ku, Sagamihara, Kanagawa 252-0373, Japan.
  • 4 Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
  • 5 Graduate School of Engineering and Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
PMID: 36282784 DOI: 10.1021/acs.jnatprod.2c00719
Abstract

Two new antiplasmodial Peptides, named koshidacins A (1) and B (2), were discovered from the culture broth of the Okinawan fungus Pochonia boninensis FKR-0564. Their structures, including absolute configurations, were elucidated by a combination of spectroscopic methods and chemical derivatization. Both compounds showed moderate in vitro antiplasmodial activity against Plasmodium falciparum strains, with IC50 values ranging from 17.1 to 0.83 μM. In addition, compound 2 suppressed 41% of malaria parasites in vivo when administered intraperitoneally at a dose of 30 mg/kg/day for 4 days.

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