2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12D inhibitor 25

KRAS G12D inhibitor 25 (Compound 148) 是 KRAS G12C 和 HSP90α 的抑制剂，IC50 分别为 <0.1 μM 和 0.1-1 μM。KRAS G12D inhibitor 25 抑制 MIA PaCa-2 和 NCI-H358 的增殖，EC50 分别为 <0.1 μM 和 0.1-1 μM。KRAS G12D inhibitor 25 降解 ERBB2，DC50 为 0.1-1 μM。

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KRAS G12D inhibitor 25 Chemical Structure

KRAS G12D inhibitor 25 Chemical Structure

CAS No. : 2768099-61-0

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KRAS G12D inhibitor 25 相关抗体

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生物活性

KRAS G12D inhibitor 25 (Compound 148) is an inhibitor for KRAS G12C and HSP90α with IC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 inhibits the proliferation of MIA PaCa-2 and NCI-H358 with EC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 degrades ERBB2 with a DC50 of 0.1-1 μM[1].

分子量

1020.61

Formula

C56H62ClN11O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS G12D inhibitor 25 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

KRAS G12D inhibitor 252768099-61-0RasBT-474MIA PaCa-2NCI-H23NCI-H358LU65AInhibitorinhibitorinhibit

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